{"id":26899,"date":"2018-03-09T09:18:56","date_gmt":"2018-03-09T09:18:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-transformacion-neoplasica-sobre-la-cantidad-y-estructura-de-las-colinesterasas-en-mama-y-ganglios-linfaticos-axilares-humanos\/"},"modified":"2018-03-09T09:18:56","modified_gmt":"2018-03-09T09:18:56","slug":"efecto-de-la-transformacion-neoplasica-sobre-la-cantidad-y-estructura-de-las-colinesterasas-en-mama-y-ganglios-linfaticos-axilares-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/efecto-de-la-transformacion-neoplasica-sobre-la-cantidad-y-estructura-de-las-colinesterasas-en-mama-y-ganglios-linfaticos-axilares-humanos\/","title":{"rendered":"Efecto de la transformaci\u00f3n neopl\u00e1sica sobre la cantidad y estructura de las colinesterasas en mama y ganglios linf\u00e1ticos axilares humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Ruiz Espejo <\/strong><\/h2>\n<p>Se investiga la expresi\u00f3n de las colinesterasas en mama normal y tumoral, as\u00ed como en ganglios axilares normales y afectados de met\u00e1stasis a consecuencia del c\u00e1ncer de mama. La mama humana contiene niveles importantes de actividades acetilcolinesterasa (ache) y butirilcolinesterasa (buche). La medida de ambas actividades en muestras pareadas normales y tumorales, tomadas de una misma paciente, revela que tras la transformaci\u00f3n neopl\u00e1stica aumenta la actividad ache y disminuye la buche.Al considerar todas las muestras normales y tumorales, la actividad ache aumenta casi al doble en las \u00faltimas, mientras que la actividad buche disminuye un 65%. El contenido de prote\u00ednas en carcinomas de mama aumenta un 30% en comparaci\u00f3n con el tejido control, lo que sugiere que la neoplasia intesifica la s\u00edntesis de prote\u00ednas en mama y\/o facilita la entrada de plasma sangu\u00edneo al epitelio mamario.  no parece que los cambios en las actividades ache y buche est\u00e9n correlacionados con par\u00e1metros clinicopatol\u00f3gicos del tumor, tales como tama\u00f1o, grado histol\u00f3gico, cantidad de re y rp, o nivel de necrosis.  cerca del 25% de la actividad ache y 70% de la buche en mama normal o tumoral se extrajeron con tamp\u00f3n salino sin detergentes; un 55% de la ache remanente se liberaron con tam\u00f3n salino m\u00e1s detergente.  los extractos de mama contiene formas g2a(87%) y gia (13%) de ache, y g4h(84%) y g1h (16%) de buche. Una fracci\u00f3n al menos de los d\u00edmeros de ache llevan restos de gpi para fijarse a las membranas. La neoplasia no afecta a la composici\u00f3n de formas moleculares de ache y buche en mama. La mayor\u00eda de las mol\u00e9culas de ache de mama se ligan a las letinas con a,lca,rca,sna y wga. La diferencia en los porcentajes de asociaci\u00f3n de wga con la ache en mama normal y tumoral revela que la neoplasia afecta al procesamiento de sus oligosac\u00e1ridos.  todas las mol\u00e9culas de ache en mama normal y tumorl se fijaron al anticuerpo hr2, y s\u00f3lo algunas al<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la transformaci\u00f3n neopl\u00e1sica sobre la cantidad y estructura de las colinesterasas en mama y ganglios linf\u00e1ticos axilares humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la transformaci\u00f3n neopl\u00e1sica sobre la cantidad y estructura de las colinesterasas en mama y ganglios linf\u00e1ticos axilares humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Ruiz Espejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cecilio Jes\u00fas Vidal Moreno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Garc\u00eda c\u00e1novas <\/li>\n<li>encarnaci\u00f3n Mu\u00f1oz delgado (vocal)<\/li>\n<li>pedro Martinez hern\u00e1ndez (vocal)<\/li>\n<li>almudena Fern\u00e1ndez briera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Ruiz Espejo Se investiga la expresi\u00f3n de las colinesterasas en mama normal y tumoral, as\u00ed como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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