{"id":26921,"date":"2018-03-09T09:18:58","date_gmt":"2018-03-09T09:18:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-y-mecanismo-de-represion-del-factor-de-transcripcion-snail-implicacion-en-la-invasion-y-progresion-tumoral\/"},"modified":"2018-03-09T09:18:58","modified_gmt":"2018-03-09T09:18:58","slug":"regulacion-de-la-expresion-y-mecanismo-de-represion-del-factor-de-transcripcion-snail-implicacion-en-la-invasion-y-progresion-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-y-mecanismo-de-represion-del-factor-de-transcripcion-snail-implicacion-en-la-invasion-y-progresion-tumoral\/","title":{"rendered":"Regulaci\u00f3n de la expresi\u00f3n y mecanismo de represi\u00f3n del factor de transcripci\u00f3n snail. implicaci\u00f3n en la invasi\u00f3n y progresi\u00f3n tumoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hector Peinado Selgas <\/strong><\/h2>\n<p>El factor de transcripci\u00f3n snail se ha caracterizado recientemente como un represor directo de la expresi\u00f3n de cadherina e en tejidos epiteliales estando implicado en la adquisici\u00f3n de un fenotipo mesenquim\u00e1tico e invasivo tras su sobreexpresi\u00f3n. Igualmente estudios durante el desarrollo embrionario han confirmado que la expresi\u00f3n de este factor de transcripci\u00f3n es esencial en el control de los procesos de transici\u00f3n epitelio mes\u00e9nquima (tem) que se produce en el desarrollo embrionario temprano. En nuestro laboratorio se ha analizado el papel de sanil en la represi\u00f3n de la adherina e en diversos modelos celulares; sin embargo se desconocen todav\u00eda en gran medida las se\u00f1ales que controlan su expresi\u00f3n, as\u00ed como del mecanismo de represi\u00f3n de cadherina e y su implicaci\u00f3n en la tumorog\u00e9nesis.  durante el desarrollo de esta tesis hemos determinado que el factor de transcripci\u00f3n snail se encuentra regulado por diversas se\u00f1ales, que tambi\u00e9n se han visto implicadas en el control de las tems durante el desarrollo y la tumorog\u00e9nesis, como son el tgfbeta1 y el fgf-2, indicando que las se\u00f1ales que regulan ambos procesos podr\u00edan ser las mismas. De igual modo, hemos determinado el mecanismo por el cual snail reprime la expresi\u00f3n de cadhereina e en diversas l\u00edneas celulares.  este mecanismo de represi\u00f3n es dependiente del reclutamiento de complejos de represi\u00f3n, en los que participan el corepresor msin3a y las histonas deacetilasas 1\/2, implicados en la modificaci\u00f3n y compactaci\u00f3n de la estructura cromat\u00ednica. Por \u00faltimo, hemos analizado la implicaci\u00f3n de snail en la tumorog\u00e9nesis y fen\u00f3menos asociados como la invasi\u00f3n celular y angiog\u00e9nesis. el an\u00e1lisis de los transfectantes estables de snail en cultivos tridimensionales in vitro e in vivo ha demostrado una correlaci\u00f3n directa entre la expresi\u00f3n de snail y la adquisici\u00f3n se encuentra implicado en los fen\u00f3menos de invasi\u00f3n local y en la progresi\u00f3n tumoral. En s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la expresi\u00f3n y mecanismo de represi\u00f3n del factor de transcripci\u00f3n snail. implicaci\u00f3n en la invasi\u00f3n y progresi\u00f3n tumoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la expresi\u00f3n y mecanismo de represi\u00f3n del factor de transcripci\u00f3n snail. implicaci\u00f3n en la invasi\u00f3n y progresi\u00f3n tumoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hector Peinado Selgas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amparo Cano Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Garese alarc\u00f3n <\/li>\n<li>angela Nieto toledano (vocal)<\/li>\n<li>manel Esteller badosa (vocal)<\/li>\n<li>Jos\u00e9 Palacios calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hector Peinado Selgas El factor de transcripci\u00f3n snail se ha caracterizado recientemente como un represor directo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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