{"id":26945,"date":"2018-03-09T09:19:00","date_gmt":"2018-03-09T09:19:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-hormona-tiroidea-y-sus-receptores-en-el-desarrollo-del-cerebelo\/"},"modified":"2018-03-09T09:19:00","modified_gmt":"2018-03-09T09:19:00","slug":"papel-de-la-hormona-tiroidea-y-sus-receptores-en-el-desarrollo-del-cerebelo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-hormona-tiroidea-y-sus-receptores-en-el-desarrollo-del-cerebelo\/","title":{"rendered":"Papel de la hormona tiroidea y sus receptores en el desarrollo del cerebelo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jimena Manzano Molt\u00f3 <\/strong><\/h2>\n<p>La hormona tiroidea (ht) es esencial para el correcto desarrollo del sistema nervioso central (snc).  la falta de ht durante el desarrollo origina alteraciones en la migraci\u00f3n y diferenciaci\u00f3n celular y en la expresi\u00f3n g\u00e9nica, provocando retraso mental y alteraciones neurol\u00f3gicas. La mayor\u00eda de las acciones de la ht tienen lugar a trav\u00e9s de la interacci\u00f3n con receptores nucleares (trs), que son factores de transcripci\u00f3n dependientes de ligando, codificados por dos genes, tralfa y trbeta. La ht controla el desarrollo del cerebelo, de modo que la ausencia de \u00e9sta orgina retraso en la migraci\u00f3n de las c\u00e9lulas granulares desde la capa granular externa hasta la capa granular interna, alteraciones en la maduraci\u00f3n de las c\u00e9lulas de purkinje e incremento en el n\u00famero de astrocitos as\u00ed como alteraciones en sus prolongaciones. Aunque la falta de hta ocasiona graves alteraciones del desarrollo, los animales deficientes de los trs son viables  y no presentan signos obvios de alteraciones en el snc. En esta tesis hemos tratado de resolver esta paradoja y de determinar la implicaci\u00f3n de las distintas isoformas de tr en el desarrollo del encef\u00e1lo. al analizar el desarrollo del cerebelo en animales tralfa1-\/- observamos que lam igraci\u00f3n de las c\u00e9lulas de purkinje  era normales, mientras que la maduraci\u00f3n de los astrocitos estaba profundamente alterada. Sorprendentemente, al inducir el hipotiroidismo en estos animales observamos una migraci\u00f3n normal de las c\u00e9lulas granulares y una maduraci\u00f3n normal de las c\u00e9lulas de purkinje y de los astrocitos. Estos resultados demuestran que el fenotipo inducido por el hipotiroidismo es consecuencia de acciones intr\u00ednsecas del receptor en ausencia de ligando. El tratamiento a animales tralfa1-\/- hipotiroides con un compuesto agonista de trbeta, gc-1, demostr\u00f3 que para el correcto desarrollo de los astrocitos del cerebelo se necesita un balance entre la acci\u00f3n de tralfa1 y trbeta.  en los \u00fa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la hormona tiroidea y sus receptores en el desarrollo del cerebelo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la hormona tiroidea y sus receptores en el desarrollo del cerebelo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jimena Manzano Molt\u00f3 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Bernal Carrasco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Garesse alarc\u00f3n <\/li>\n<li>Luis Miguel Garc\u00eda segura (vocal)<\/li>\n<li>pere Berbel navarro (vocal)<\/li>\n<li>elisa Marti gorostiza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jimena Manzano Molt\u00f3 La hormona tiroidea (ht) es esencial para el correcto desarrollo del sistema nervioso central [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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