{"id":26960,"date":"2018-03-09T09:19:01","date_gmt":"2018-03-09T09:19:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/crecimiento-precoz-de-la-hemorragia-cerebral-primaria-relacion-con-marcadores-moleculares-inflamatorios-y-de-ruptura-de-la-barrera-hemato-encefalica\/"},"modified":"2018-03-09T09:19:01","modified_gmt":"2018-03-09T09:19:01","slug":"crecimiento-precoz-de-la-hemorragia-cerebral-primaria-relacion-con-marcadores-moleculares-inflamatorios-y-de-ruptura-de-la-barrera-hemato-encefalica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/crecimiento-precoz-de-la-hemorragia-cerebral-primaria-relacion-con-marcadores-moleculares-inflamatorios-y-de-ruptura-de-la-barrera-hemato-encefalica\/","title":{"rendered":"Crecimiento precoz de la hemorragia cerebral primaria: relaci\u00f3n con marcadores moleculares inflamatorios y de ruptura de la barrera hemato-encef\u00e1lica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Seijo Mart\u00ednez <\/strong><\/h2>\n<p>Introducci\u00f3n  la hemorragia cerebral primaria (hic) constituye aproximadamente 10-17% de todos los ictus y cursa con una elevada morbilidad y mortalidad. Cl\u00e1sicamente se cre\u00eda que la hemorragia era un evento monofasico. Informaci\u00f3n reciente indica que el crecimiento, o el aumento del volumen, precoz de la hemorragia puede aaprecer en una proporci\u00f3n significativo de pacientes con hic y estar asociada con deterioro neurol\u00f3gico precoz, mortalidad y mal pron\u00f3stico. los factores patog\u00e9nicos que determinan el crecimiento precoz de la hemorragia cerebral permanecen, en gran parte, desconocidos.  objetivo  el objetivo de este trabajo es el estudio del crecimiento precoz de la hic y su relaci\u00f3n con par\u00e1metros cl\u00ednico-radiol\u00f3gicos y concentraciones plasm\u00e1ticas de interleukina-6 (l-6), factor de necrosis tumoral alfa (tnfa), metaloproteasa 9 (mmp-9) y fibronectina celular (cfbn).  material y m\u00e9todos  estudio prospectivo de 78 pacientes con hic supratentorial ingresados en las primeras 12 tras el ictus. La tomograf\u00eda axial computarizada (tac) cerebral fue repetida a las 48 horas. Para hemorragias superiores a 20 ml crecimiento fue definido como aumento del volumen en 10%; para hemorragias inferiores a 10 ml crecimiento fue definido como aumento en 33%. Las concentraciones de il-6, tnfa, mmp-9, cfn y otros par\u00e1metros bioqu\u00edmicos y hematol\u00f3gicos fueron obtenidas en las muestras al ingreso. Diversos par\u00e1metros cl\u00ednicos y radiol\u00f3gicos fueron recogidos al ingreso y a las 48 horas. La severidad del ictus fue valorado mediante la escala canadiense de ictus. Se realizaron estudios estad\u00edsticos apropiados, an\u00e1lisis univariante y multivariante mediante regresi\u00f3n log\u00edstica.  resultados  30,8% de los pacientes de la cohorte presentaron crecimiento precoz resulto estar significativamente asociado con el deterioro neurol\u00f3gico (or 16). en el an\u00e1lisis univariante, la temperatura corporal, velocidad de sedimentaci\u00f3n en la 1\u00aa hor<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Crecimiento precoz de la hemorragia cerebral primaria: relaci\u00f3n con marcadores moleculares inflamatorios y de ruptura de la barrera hemato-encef\u00e1lica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Crecimiento precoz de la hemorragia cerebral primaria: relaci\u00f3n con marcadores moleculares inflamatorios y de ruptura de la barrera hemato-encef\u00e1lica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Seijo Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Castillo S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Noya  Garc\u00eda <\/li>\n<li>Francisco Rubio borrego (vocal)<\/li>\n<li>alfredo Garc\u00eda allut (vocal)<\/li>\n<li>Jos\u00e9 Vivancos mora (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Seijo Mart\u00ednez Introducci\u00f3n la hemorragia cerebral primaria (hic) constituye aproximadamente 10-17% de todos los ictus y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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