{"id":26964,"date":"2018-03-09T09:19:01","date_gmt":"2018-03-09T09:19:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caractera%c2%adsticas-de-accion-del-glp-1-sobre-el-transporte-de-glucosa-en-el-musculo-del-hombre-normal-y-diabetico\/"},"modified":"2018-03-09T09:19:01","modified_gmt":"2018-03-09T09:19:01","slug":"caractera%c2%adsticas-de-accion-del-glp-1-sobre-el-transporte-de-glucosa-en-el-musculo-del-hombre-normal-y-diabetico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caractera%c2%adsticas-de-accion-del-glp-1-sobre-el-transporte-de-glucosa-en-el-musculo-del-hombre-normal-y-diabetico\/","title":{"rendered":"Caracter\u00edsticas de acci\u00f3n del glp-1 sobre el transporte de glucosa en el m\u00fasculo del hombre normal y diab\u00e9tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nieves Gonz\u00e1lez G\u00f3mez <\/strong><\/h2>\n<p>Las aportaciones originales del estudio se pueden resumir en lo siguiente:  1,- que el glp-1, como la insulina, incrementa el transporte de glucosa y el metabolismo del gluc\u00f3geno en el m\u00fasculo esquel\u00e9tico del hombre normal &#8211; miocitos en cultivo primario -, y que si bien ambas hormonas parecen compartir la activaci\u00f3n de algunos enzimas iniciales en las v\u00edas de se\u00f1alizaci\u00f3n -pi3k, mapks y p70s6k-, no parece probable que un incremento en la fosforilaci\u00f3n de la p70s6k sea esencial en estas acciones del glp-1. Que la ex-4 y la ex9 no s\u00f3lo mimentizan el efecto del glp-1, con qui\u00e9n est\u00e1n estructuralmente relacionadas, sino que aparentemente son agonistas de la acci\u00f3n de \u00e9ste sobre el transporte de la glucosa en el m\u00fasculo aunque, posiblemente, a trav\u00e9s de un mecanismo distinto. De hecho, ambas exendinas tambi\u00e9n activan la pi3k\/pkb y mapks, pero en su efecto podr\u00edan intervenir, adem\u00e1s de estas enzimas, isoformas t\u00edpicas de la pkc (alfa, beta1, beta3 y gamma); por otro lado, e independientemente de que tambi\u00e9n ambas inducen la hidr\u00f3lisis inmediata de gpls, la ex-4, sin embargo, y a diferencia con el glp-1 y ex-9, propicia un peque\u00f1o pero claro aumento en le contenido celular de ampc.  2,- y que los resultados del estudio en c\u00e9lulas de pacientes diab\u00e9ticos tipo 2, permiten concluir que el efecto del glp-1 sobre el transporte de glucosa, y tambi\u00e9n el de ambas exendinas, est\u00e1 mantenido, por lo que el deterioro observado en estados basales, previos a su activaci\u00f3n por glp-1, insulina, y tambi\u00e9n por ambas exendinas, parece pudiera ser compensado por el desarrollo de una mayor sensibilidad en la v\u00eda de las mpaks, no particularmente frente a la insulina, pero s\u00ed en lo relativo al glp-1 y, sobre todo, a la ex-4 y ex-9.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracter\u00edsticas de acci\u00f3n del glp-1 sobre el transporte de glucosa en el m\u00fasculo del hombre normal y diab\u00e9tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracter\u00edsticas de acci\u00f3n del glp-1 sobre el transporte de glucosa en el m\u00fasculo del hombre normal y diab\u00e9tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nieves Gonz\u00e1lez G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>pe\u00f1acarrillo Molina Villanueva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Bl\u00e1zquez fern\u00e1ndez <\/li>\n<li>isabel Valverde alonso (vocal)<\/li>\n<li>Jos\u00e9 enrique Campillo \u00e1lvarez (vocal)<\/li>\n<li>david Vicent l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nieves Gonz\u00e1lez G\u00f3mez Las aportaciones originales del estudio se pueden resumir en lo siguiente: 1,- que el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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