{"id":27026,"date":"2018-03-09T09:19:07","date_gmt":"2018-03-09T09:19:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-las-infecciones-naturales-y-experimentales-del-raton-de-laboratorio-sobre-la-progresion-metastatica-del-melanoma-murino-b16\/"},"modified":"2018-03-09T09:19:07","modified_gmt":"2018-03-09T09:19:07","slug":"efecto-de-las-infecciones-naturales-y-experimentales-del-raton-de-laboratorio-sobre-la-progresion-metastatica-del-melanoma-murino-b16","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/efecto-de-las-infecciones-naturales-y-experimentales-del-raton-de-laboratorio-sobre-la-progresion-metastatica-del-melanoma-murino-b16\/","title":{"rendered":"Efecto de las infecciones naturales y experimentales del rat\u00f3n de laboratorio sobre la progresi\u00f3n metast\u00e1tica del melanoma murino b16"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodr\u00edguez Cuesta Juan  Angel <\/strong><\/h2>\n<p>Los modelos experimentales de carcinog\u00e9nesis y progresi\u00f3n metast\u00e1tica de tumores animales constituyen una herramienta imprescindible para el estudio fisiopatol\u00f3gico y la b\u00fasqueda de terap\u00e9uticas innovadoras contra el c\u00e1ncer. sin embargo, existen determinados microorganismos capaces de infectar a los animales durante la fase experimental. Las infecciones pueden provocar cambios fisiopatol\u00f3gicos, alterar la respuesta inmune e incrementar la variabilidad entre individuos de un mismo grupo experimental. Recientemente, hemos demostrado que citocinas proinflamatorias, tales como el factor de necrosis tumoral-alfa (tnf-alfa) y la interleucina-18 (il-18), producen efectos pro-adhesivos y pro-angiog\u00e9nicos que estimulan el proceso metast\u00e1tico. no obstante, no se conoce con precisi\u00f3n el impacto de las elevaciones en los niveles end\u00f3genos de tales citocinas inflamatorias inducidas por agentes infecciosos sobre la progresi\u00f3n metast\u00e1tica en animales de laboratorio.  en este trabajo se estudi\u00f3 si las infecciones naturales y experimentales en el rat\u00f3n influyen sobre la capacidad metast\u00e1tica de las c\u00e9lulas del melanoma murino b16 (mb16).  para ello se utilizaron animales con diferente procedencia en los que se analiz\u00f3 su estado sanitario a trav\u00e9s de un amplio prgrama de monitorizaci\u00f3n sanitaria. Se compar\u00f3 la capacidad de las c\u00e9lulas del melanoma para colonizar el h\u00edgado de animales mantenidos bajo diferentes condiciones experimentales. posteriormente, se cuantific\u00f3 en estos animales la concentraci\u00f3n s\u00e9rica de algunas citoquinas.  se puede concluir que, tanto las infecciones naturales como la infecci\u00f3n con c.Albicans, son capaces de incrementar la capacidad de las c\u00e9lulas cancer\u00edgenas para colonizar el tejido hep\u00e1tico, probablemente a trav\u00e9s de un mecanismo dependiente de la elevaci\u00f3n del tnf-alfa y la il-18.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de las infecciones naturales y experimentales del rat\u00f3n de laboratorio sobre la progresi\u00f3n metast\u00e1tica del melanoma murino b16<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de las infecciones naturales y experimentales del rat\u00f3n de laboratorio sobre la progresi\u00f3n metast\u00e1tica del melanoma murino b16 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodr\u00edguez Cuesta Juan  Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Mart\u00ednez De Tejada De Garaiz\u00e1bal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Hernando echeverr\u00eda Fernando Luis <\/li>\n<li> Juste jordan ram\u00f3n a. (vocal)<\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Blasco Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodr\u00edguez Cuesta Juan Angel Los modelos experimentales de carcinog\u00e9nesis y progresi\u00f3n metast\u00e1tica de tumores animales constituyen una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[77843,77844,53895,43302,69509,77842],"class_list":["post-27026","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-guillermo-Martinez-de-tejada-de-garaizabal","tag-hernando-echeverria-fernando-luis","tag-jesus-garcia-foncillas-lopez","tag-jose-maria-blasco-Martinez","tag-juste-jordan-ramon-a","tag-rodriguez-cuesta-juan-angel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27026"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27026\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}