{"id":27041,"date":"2018-03-09T09:19:08","date_gmt":"2018-03-09T09:19:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-de-la-resonancia-magnetica-en-el-estudio-genetico-clinico-de-la-esclerosis-multiple-familiar\/"},"modified":"2018-03-09T09:19:08","modified_gmt":"2018-03-09T09:19:08","slug":"utilidad-de-la-resonancia-magnetica-en-el-estudio-genetico-clinico-de-la-esclerosis-multiple-familiar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/utilidad-de-la-resonancia-magnetica-en-el-estudio-genetico-clinico-de-la-esclerosis-multiple-familiar\/","title":{"rendered":"Utilidad de la resonancia magnetica en el estudio genetico clinico de la esclerosis multiple familiar"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Osama Barakat Shrem <\/strong><\/h2>\n<p>Introducci\u00f3n: la esclerosis m\u00faltiple (em) es una de las enfermedades m\u00e1s discapacitantes, que afecta a pacientes j\u00f3venes. La etiopatogenia de la enfermedad es desconocida. Existe un consenso sobre la participaci\u00f3n de factores ex\u00f3genos, poco conocidos y una predisposici\u00f3n gen\u00e9tica individual. la existencia de familias con varios miembros afectos de esclerosis m\u00faltiple, que se ha dado a conocer como esclerosis m\u00faltiple familiar (emf), es la mejor muestra de la existencia de dicha herencia gen\u00e9tica. La forma hereditaria de la enfermedad es desconocida, sobretodo debido a la existencia de casos asintom\u00e1ticos que, en ocasiones, no llegan a desarrollar la enfermedad.  objetivos: localizar familias con varios casos de emf en su seno, practicar resonancia magn\u00e9tica cerebrales (rm) al mayor n\u00famero de sus miembros asintom\u00e1ticos, para localizar lesiones radiol\u00f3gicas compatible con la enfermedad y poder construir \u00e1rboles geneal\u00f3gicos que hagan m\u00e1s comprensible la forma de transmisi\u00f3n de la lesi\u00f3n estructural de la enfermedad en estas familias.  pacientes y metodos: se investigan los antecedentes familiares de los 430 pacientes de em que forman parte de la base de datos de la unidad de seguimiento de esclerosis m\u00faltiple del hospital universitario virgen macarena de sevilla. se identifican las familias con varios miembros con emf. Se practica rm a los familiares cercanos y se comparan con las practicadas a voluntarios sanos.  resultados: encontramos 44 casos de emf entre los 430 pacientes con fm de nuestra base de datos. Se consigue la colaboraci\u00f3n de las familias de 36 de ellos. Se practica rm a un total de 31 familiares, con una edad media de 46,8 a\u00f1os, resultando compatibles con lesiones desmielinizantes en 17 de ellos. En 16 rm las lesiones fueron periventriculares, en 13 fueron hemisf\u00e9ricas y en 3 en fosa posterior. Las rm fueron patol\u00f3gicas en 8 de las 12 practicadas a pasres de pacientes, a 6 a 9 hermanos y a 3 de 10<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad de la resonancia magnetica en el estudio genetico clinico de la esclerosis multiple familiar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad de la resonancia magnetica en el estudio genetico clinico de la esclerosis multiple familiar <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Osama Barakat Shrem <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Izquierdo Ayuso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fajardo galvez <\/li>\n<li>Miguel Lucas lucas (vocal)<\/li>\n<li> Fernandez perez Mar\u00eda  Jos\u00e9 (vocal)<\/li>\n<li>Luis Redondo vergel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Osama Barakat Shrem Introducci\u00f3n: la esclerosis m\u00faltiple (em) es una de las enfermedades m\u00e1s discapacitantes, que afecta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10715],"tags":[77870,70014,1883,77871,41741,77869],"class_list":["post-27041","post","type-post","status-publish","format-standard","hentry","category-sevilla","tag-fernandez-perez-maria-jose","tag-guillermo-izquierdo-ayuso","tag-jose-fajardo-galvez","tag-luis-redondo-vergel","tag-miguel-lucas-lucas","tag-osama-barakat-shrem"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27041"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27041\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}