{"id":27098,"date":"2018-03-09T09:19:13","date_gmt":"2018-03-09T09:19:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-perdida-total-de-expresion-de-moleculas-hla-de-clase-i-y-perdida-selectiva-de-b44-en-tumores-de-colon\/"},"modified":"2018-03-09T09:19:13","modified_gmt":"2018-03-09T09:19:13","slug":"bases-moleculares-de-la-perdida-total-de-expresion-de-moleculas-hla-de-clase-i-y-perdida-selectiva-de-b44-en-tumores-de-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-perdida-total-de-expresion-de-moleculas-hla-de-clase-i-y-perdida-selectiva-de-b44-en-tumores-de-colon\/","title":{"rendered":"Bases moleculares de la p\u00e9rdida total de expresi\u00f3n de mol\u00e9culas hla de clase i y p\u00e9rdida selectiva de b44 en tumores de colon"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cabrera Morales Carmen M. <\/strong><\/h2>\n<p>En los tumores de colon tanto el mecanismo como la frecuencia de la p\u00e9rdida o defecto de expresi\u00f3n de mol\u00e9culas hla de clase i se conoce de forma parcial. plante\u00e1ndose por tanto, el estudio de los mecanismos moleculares implicados en tales p\u00e9rdidas, en concreto la p\u00e9rdida total de expresi\u00f3n de mol\u00e9culas hla  de clase i (fenotipo i) y la p\u00e9rdida selectiva del alelo hla-b44 (fenotipo iv). En el grupo de tumores con p\u00e9rdida total de expresi\u00f3n de mol\u00e9culas hla de clase i (14 a 95) se encontraron dos mecanismos principales implicados:  a,- la p\u00e9rdida de la funci\u00f3n g\u00e9nica del gen de beta2m como resutlado de una inactivaci\u00f3n bialelica (mutaciones y\/o posible loh) en los tumores de colon que presentan inestabilidad de microsat\u00e9lites (msi) (4 de 14).  b,- el defecto transcripcional de genes implicados en el procesamiento y presentaci\u00f3n antig\u00e9nica lmp7 y tap2 en el grupo de tumores con ausencia de inestabilidad de microsat\u00e9lites (mss) (10 a 14); estando adem\u00e1s asociado el defecto de lmp7 a una alteraci\u00f3n del patr\u00f3n nuclear de los cuerpos de pml afect\u00e1ndose de este modo tanto el repertorio de p\u00e9ptidos antig\u00e9nicos generados en el citoplasma como en en n\u00facleos celular.  en el estudio de p\u00e9rdida selectiva del alelo b44 que es el que presenta una mayor frecuencia de p\u00e9rdida en tumores de colon, se encuentran mecanismos que implican bien la p\u00e9rdida de haplotipo en un peque\u00f1o n\u00famero de casos (4-13)y en la mayor\u00eda (9 de 13) el defecto post-transcripcional relacionado con el defecto de expresi\u00f3n de la chaperona tapasina, componente del complejo de carga p\u00e9ptidico de clase i.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases moleculares de la p\u00e9rdida total de expresi\u00f3n de mol\u00e9culas hla de clase i y p\u00e9rdida selectiva de b44 en tumores de colon<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases moleculares de la p\u00e9rdida total de expresi\u00f3n de mol\u00e9culas hla de clase i y p\u00e9rdida selectiva de b44 en tumores de colon <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cabrera Morales Carmen M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>cabello  Osuna Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel L\u00f3pez botet <\/li>\n<li>Javier Oliver pozo (vocal)<\/li>\n<li>Miguel angel Piris pinilla (vocal)<\/li>\n<li>Javier Martin iba\u00f1ez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cabrera Morales Carmen M. En los tumores de colon tanto el mecanismo como la frecuencia de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[4019,78003,45178,78004,30250,15393],"class_list":["post-27098","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-cabello-osuna-ruiz","tag-cabrera-morales-carmen-m","tag-javier-martin-ibanez","tag-javier-oliver-pozo","tag-miguel-angel-piris-pinilla","tag-miguel-lopez-botet"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27098"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27098\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}