{"id":27136,"date":"2018-03-09T09:19:16","date_gmt":"2018-03-09T09:19:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-sistema-gabaergico-en-el-mecanismo-de-secrecion-de-insulina\/"},"modified":"2018-03-09T09:19:16","modified_gmt":"2018-03-09T09:19:16","slug":"implicacion-del-sistema-gabaergico-en-el-mecanismo-de-secrecion-de-insulina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-sistema-gabaergico-en-el-mecanismo-de-secrecion-de-insulina\/","title":{"rendered":"Implicaci\u00f3n del sistema gaba\u00e9rgico en el mecanismo de secreci\u00f3n de insulina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Fern\u00e1ndez Pascual <\/strong><\/h2>\n<p>La l-glutamina, que carece de capacidad secretora alguna, es, sin embargo, metabolizada por islotes pancre\u00e1ticos a velocidad equiparable a la de la d-glucosa, el secretagogo fisiol\u00f3gico de insulina. La l-glutamina origina, durante su metabolismo en islotes, grandes cantidades de l-glutamato, l-aspartato y gaba. Este gaba es sintetizado a partir de l-glutamato por acci\u00f3n de la glutamato \u00e1cido decarboxilasa (gad). Este enzima, en su isoforma de 65 kda, es el ant\u00edgeno de mayor preValencia en la diabetes mellitus de tipo i (insulino-dependiente, o diabetes infantil). La l-glutamina potencia la secreci\u00f3n estimulada por determinados alfa-ceto\u00e1cidos ramificados, alfa-amino\u00e1cidos y la propia d-glucosa, lo que se acompa\u00f1a con un descenso en los niveles intracelulares de gaba procedente del metabolismo de la l-glutamina. Este descenso de gaba intracelular es debido a un aumento del metabolismo del amino\u00e1cido y no al aumento de su liberaci\u00f3n mediante exocitosis de microves\u00edculas de tipo sin\u00e1ptico (slmvs). El aumento de los niveles intracelulares de gaba mediante derivados permeabilizados (etil o metil \u00e9steres) de gaba (o su an\u00e1logo estructural, la beta-alanina) provoca una fuerte inhibici\u00f3n de la secreci\u00f3n de insulina, as\u00ed como la inhibici\u00f3n de la oxidaci\u00f3n de d-glucosa, la velocidad de glicolisis y la fosforilaci\u00f3n del monosac\u00e1rido, sin afectar al metabolismo del piruvato en el ciclo de krebs. Este efecto metab\u00f3lico del aumento de los niveles intracelulares de gaba, es la consecuencia del consumo de atp por el transporte de la amina a slmvs, proceso que compite con el cierre de los canales de potasio sensibles a atp. La consecuencia final de la competencia entre ambos procesos que requieren atp es la no despolarizaci\u00f3n de la membrana plasm\u00e1tica en respuesta a est\u00edmulos secretores, lo que produce la inhibici\u00f3n de la exocitosis de los gr\u00e1nulos de secreci\u00f3n que contienen insulina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n del sistema gaba\u00e9rgico en el mecanismo de secreci\u00f3n de insulina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n del sistema gaba\u00e9rgico en el mecanismo de secreci\u00f3n de insulina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Fern\u00e1ndez Pascual <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Tamarit Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Barrientos guzm\u00e1n <\/li>\n<li>fatima Bosch tubert (vocal)<\/li>\n<li>Rafael Mart\u00edn del r\u00edo (vocal)<\/li>\n<li>Francisco Mart\u00edn bermudo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Fern\u00e1ndez Pascual La l-glutamina, que carece de capacidad secretora alguna, es, sin embargo, metabolizada por islotes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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