{"id":27154,"date":"2018-03-09T09:19:18","date_gmt":"2018-03-09T09:19:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-farmacocineticos-y-biofarmaceuticos-del-acamprosato-en-la-rata\/"},"modified":"2018-03-09T09:19:18","modified_gmt":"2018-03-09T09:19:18","slug":"estudios-farmacocineticos-y-biofarmaceuticos-del-acamprosato-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-farmacocineticos-y-biofarmaceuticos-del-acamprosato-en-la-rata\/","title":{"rendered":"Estudios farmacocin\u00e9ticos y biofarmac\u00e9uticos del acamprosato en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teodoro Zornoza Sabina <\/strong><\/h2>\n<p>El acamprosato o bis-acetilhomoaurinato c\u00e1lcico es un f\u00e1rmaco que se emplea en la terapia de mantenimiento de la abstinencia en pacientes dependientes del alcohol. Sin embargo, uno de los problemas m\u00e1s importantes en su manejo cl\u00ednico derivada de su reducida biodisponibilidad oral en magnitud (bd), que se sit\u00faa en torno a un 11% en humanos. Por ello, mediante el empleo de diversos y sencillos dise\u00f1os experimentales se ha abordado el estudio de dos de los procesos menos conocidos de su farmacocin\u00e9tica, la absorci\u00f3n y la eliminaci\u00f3n.  el estudio de la linealidad farmacocin\u00e9tica del acamprosato se ha realizado tras la administraci\u00f3n intravenosa r\u00e1pida de 2.8, 11 \u00f3 22 mg del f\u00e1rmaco, as\u00ed como tras su perfusi\u00f3n endovenosa a 2.6, 132.5 \u00f3 530.0 ug\/min. La comparaci\u00f3n de los principales par\u00e1metros farmacocin\u00e9ticos obtenidos, no revel\u00f3 ninguna diferencia estad\u00edsticamente significativa entre ellos.  por tanto, a tenor de los resultados obtenidos parece ser que el acamprosato presenta una disposici\u00f3n lineal en el \u00e1mbito de concentraciones estudiadas, tanto en condiciones de estado estacionario como tras su administraci\u00f3n intravenosa r\u00e1pida.  en lo relativo a su eliminaci\u00f3n, nuestros resultados indican claramente que el acamprosato se elimina inalterado por v\u00eda renal casi en exclusividad (u48 o=95.0 +- 13.9%). Los elevados valores de aclaramiento total estimados tras la administraci\u00f3n intravenosa r\u00e1pida de diferentes dosis de acamprosato, as\u00ed como los de aclaramiento total y renal calculados en estado estacionario, sugieren que la filtraci\u00f3n glomerular, que podr\u00eda ser responsable de los elevados valores de aclaramiento del f\u00e1rmaco, se administr\u00f3 conjuntamente al acamprostao con probenecid, conocido inhibidor de la secreci\u00f3n tubular activa. Los niveles plasm\u00e1ticos promedios del f\u00e1rmaco en los animales tratados con probenecid (10 \u00f3 20 mg) fueron claramente superiores a los obtenidos en el grupo control, obteni\u00e9<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios farmacocin\u00e9ticos y biofarmac\u00e9uticos del acamprosato en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios farmacocin\u00e9ticos y biofarmac\u00e9uticos del acamprosato en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teodoro Zornoza Sabina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Polache Vengut<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marina Herraez dominguez <\/li>\n<li>Juan Sastre belloch (vocal)<\/li>\n<li>martiniano Santiago pav\u00f3n (vocal)<\/li>\n<li> Mart\u00edn algarra Rafael vicente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teodoro Zornoza Sabina El acamprosato o bis-acetilhomoaurinato c\u00e1lcico es un f\u00e1rmaco que se emplea en la terapia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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