{"id":27155,"date":"2018-03-09T09:19:18","date_gmt":"2018-03-09T09:19:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-vitamina-a-sobre-la-expresion-genica-en-distintos-tejidos-de-mama%c2%adferos\/"},"modified":"2018-03-09T09:19:18","modified_gmt":"2018-03-09T09:19:18","slug":"efecto-de-la-vitamina-a-sobre-la-expresion-genica-en-distintos-tejidos-de-mama%c2%adferos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-vitamina-a-sobre-la-expresion-genica-en-distintos-tejidos-de-mama%c2%adferos\/","title":{"rendered":"Efecto de la vitamina a sobre la expresi\u00f3n g\u00e9nica en distintos tejidos de mam\u00edferos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elisa Borr\u00e1s Blasco <\/strong><\/h2>\n<p>Estudios moleculares y gen\u00e9ticos han puesto de manifiesto que la funci\u00f3n celular viene determinada por el resultado de la interacci\u00f3n entre la informaci\u00f3n gen\u00e9tica y las variables medioambientales. Los alimentos tiene dos formas de influir sobre la expresi\u00f3n g\u00e9nica, de forma directa e indirecta. En la actualidad las t\u00e9cnicas m\u00e1s utilizadas para el estudio de esta variaci\u00f3n gen\u00e9tica, producida por los alimentos o las condiciones medioambientales, son el differencial display y los microrray chips. Ambas son t\u00e9cnicas complementarias y no excluyentes.  la estructura, el metabolismo y las funciones de la vitamina a (y sus derivados) se est\u00e1n estudiando desde el descubrimiento de esta mol\u00e9cula. Se ha demostrado que tanto la deficiencia de vitamina a como la hipervitaminosis provocan s\u00edntomas cl\u00ednicos. Algunos de los ensayos cl\u00ednicos de administraci\u00f3n de vitamina a son el atbc, el caret y el phs, en los cuales se les administraba vitamina a a pacientes con riesgo de desarrollo de c\u00e1ncer o enfermedad cardiovascular y se observ\u00f3 que \u00e9stos ten\u00edan una mayor tendencia a desarrollar estas enfermedades que los pacientes que tomaban placebo.  el objetivo buscado con esta tesis es estudiar si el da\u00f1o celular que produce la dificiencia de dna es causado por cambios en la expresi\u00f3n g\u00e9nica. Para ello hemos utilizado, entre otras, una de las t\u00e9cnicas que se han nombrado anteriormente, el differential display.  mediante esta t\u00e9cnica hemos descubierto que los genes ras y p53 sufren variaciones en su expresi\u00f3n g\u00e9nica en ratas deficientes en vitamina a. mientras que ras sufre un aumento de su expresi\u00f3n, el gen p53 disminuye. tambi\u00e9n estudiamos qu\u00e9 ocurr\u00eda con genes directamente relacionados con estos dos en el ciclo celular. Los genes seleccionados fueron c-jun y p21. la expresi\u00f3n de c-jun (activado por ras) disminu\u00eda en ratas deficientes, mientras que el gen p21 (activado por p53) aumentaba. Estos resultados se repitieron ta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la vitamina a sobre la expresi\u00f3n g\u00e9nica en distintos tejidos de mam\u00edferos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la vitamina a sobre la expresi\u00f3n g\u00e9nica en distintos tejidos de mam\u00edferos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elisa Borr\u00e1s Blasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Vi\u00f1a Ribes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Cabo soler <\/li>\n<li> Ruiz Garc\u00eda trevijano Elena (vocal)<\/li>\n<li>mat\u00edas Antonio \u00e1vila zaragoz\u00e1 (vocal)<\/li>\n<li>pedro Puig parellada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elisa Borr\u00e1s Blasco Estudios moleculares y gen\u00e9ticos han puesto de manifiesto que la funci\u00f3n celular viene determinada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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