{"id":27211,"date":"2003-01-12T00:00:00","date_gmt":"2003-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/muerte-neuronal-excitotoxica-interaccion-entre-las-rutas-de-senalizacion-del-igf-i-y-el-glutamato\/"},"modified":"2003-01-12T00:00:00","modified_gmt":"2003-01-12T00:00:00","slug":"muerte-neuronal-excitotoxica-interaccion-entre-las-rutas-de-senalizacion-del-igf-i-y-el-glutamato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/muerte-neuronal-excitotoxica-interaccion-entre-las-rutas-de-senalizacion-del-igf-i-y-el-glutamato\/","title":{"rendered":"Muerte neuronal excitot\u00f3xica: interacci\u00f3n entre las rutas de se\u00f1alizaci\u00f3n del igf-i y el glutamato"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Garc\u00eda Galloway <\/strong><\/h2>\n<p>El igf-i es capaz de promover supervivencia neuronal, en esta capacidad est\u00e1 implicada una de las rutas de se\u00f1alizaci\u00f3n m\u00e1s estudiadas de este factor tr\u00f3fico, la v\u00eda de la pi3 quinasa\/akt (dudek et al., 1997). En el presente trabajo hemos comprobado como las dosis excitot\u00f3xicas de glutamato interfieren con estas v\u00eda de supervivencia del igf-i. Nuestro resultado, junto a observaciones recientes en las que se demuestra la p\u00e9rdida de sensibilidad a la insulina y\/o igf-i en diferentes tipos de condiciones neurodegenerativas (ostlund et al., 2001; peretz et al 2001; venters et al., 1999), dan una nueva perspectiva en la que se\u00f1ales citot\u00f3xicas pueden operar interfiriendo con rutas neurotr\u00f3ficas. En esta nueva interpretaci\u00f3n, el exceso de glutamato ser\u00eda tambi\u00e9n neurot\u00f3xico por ser capaz de atenuar la se\u00f1al tr\u00f3fica del igf-i. En principio, esta hip\u00f3tesis parecer\u00eda contradictoria con otros estudios que otorgan un papel fundamental al calcio intracelular en la excitotoxicidad del glutamato (sattler et al., 2000), pero no lo es, ya que se podr\u00eda considerar esta p\u00e9rdida de sensibilidad al igf-i como una ruta paralela implicada en la muerte neuronal por glutamato.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Muerte neuronal excitot\u00f3xica: interacci\u00f3n entre las rutas de se\u00f1alizaci\u00f3n del igf-i y el glutamato<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Muerte neuronal excitot\u00f3xica: interacci\u00f3n entre las rutas de se\u00f1alizaci\u00f3n del igf-i y el glutamato <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Garc\u00eda Galloway <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Torres Alem\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: margarita Lorenzo balado <\/li>\n<li>Francisco Wandosell jurado (vocal)<\/li>\n<li>Luis Miguel Garc\u00eda segura (vocal)<\/li>\n<li>federico Mallo ferrer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Garc\u00eda Galloway El igf-i es capaz de promover supervivencia neuronal, en esta capacidad est\u00e1 implicada una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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