{"id":27222,"date":"2003-01-12T00:00:00","date_gmt":"2003-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-fosforilacion-de-serinas-y-el-plegamiento-de-autoanta%c2%adgenos-caracterizacion-de-gpbp-una-nueva-quinasa-implicada-en-autoinmunidad\/"},"modified":"2003-01-12T00:00:00","modified_gmt":"2003-01-12T00:00:00","slug":"la-fosforilacion-de-serinas-y-el-plegamiento-de-autoanta%c2%adgenos-caracterizacion-de-gpbp-una-nueva-quinasa-implicada-en-autoinmunidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-fosforilacion-de-serinas-y-el-plegamiento-de-autoanta%c2%adgenos-caracterizacion-de-gpbp-una-nueva-quinasa-implicada-en-autoinmunidad\/","title":{"rendered":"La fosforilaci\u00f3n de serinas y el plegamiento de autoant\u00edgenos: caracterizaci\u00f3n de gpbp, una nueva quinasa implicada en autoinmunidad"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00ednez Mart\u00ednez M. Pilar <\/strong><\/h2>\n<p>En esta tesis doctoral hemos investigado el papel de la foforilaci\u00f3n en el plegamiento de la prote\u00edna b\u00e1sica en la mielina (pbm*ii) y su implicaci\u00f3n en la correspondiente respuesta autoinmune.  nuestros resultados sugieren que en la patog\u00e9nesis una fosforilaci\u00f3n aberrante de la (pbm*ii), podr\u00edan generar especies moleculares m\u00e1s uniformes y resistentes a la degradaci\u00f3n que constratar\u00edan con las pbm*ii en condiciones de normalidad.  adicionalmente se ha investigado la expresi\u00f3n celular y la interacci\u00f3n de gpbp con prote\u00ednas implicadas en la patogenia autoinmune y degenerativa, comprob\u00e1ndose que est\u00e1 prote\u00edna presenta una localizaci\u00f3n muy heterog\u00e9nea, as\u00ed como su forma m\u00e1s com\u00fan no corresponde a una prote\u00edna generada desde su metionina can\u00f3nica.  finalmente, se ha demostrado su interacci\u00f3n con prote\u00ednas implicadas en la patogenia autoinmune y degenerativa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La fosforilaci\u00f3n de serinas y el plegamiento de autoant\u00edgenos: caracterizaci\u00f3n de gpbp, una nueva quinasa implicada en autoinmunidad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La fosforilaci\u00f3n de serinas y el plegamiento de autoant\u00edgenos: caracterizaci\u00f3n de gpbp, una nueva quinasa implicada en autoinmunidad <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00ednez Mart\u00ednez M. Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Saus Mas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: roberto Erwin knecht <\/li>\n<li>enrique Perez paya (vocal)<\/li>\n<li>Juan  Jos\u00e9 Calvete chornet (vocal)<\/li>\n<li>joaqu\u00edn Timoneda timoneda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00ednez Mart\u00ednez M. Pilar En esta tesis doctoral hemos investigado el papel de la foforilaci\u00f3n en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[34359,19179,56559,52389,78279,19180],"class_list":["post-27222","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-enrique-perez-paya","tag-joaquin-timoneda-timoneda","tag-juan-jose-calvete-chornet","tag-juan-saus-mas","tag-Martinez-Martinez-m-pilar","tag-roberto-erwin-knecht"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27222"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27222\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}