{"id":27264,"date":"2003-03-12T00:00:00","date_gmt":"2003-03-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-infiltracion-tumoral-por-celulas-natural-killer-en-el-cancer-de-pulmon-no-celulas-pequenas\/"},"modified":"2003-03-12T00:00:00","modified_gmt":"2003-03-12T00:00:00","slug":"valor-pronostico-de-la-infiltracion-tumoral-por-celulas-natural-killer-en-el-cancer-de-pulmon-no-celulas-pequenas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-infiltracion-tumoral-por-celulas-natural-killer-en-el-cancer-de-pulmon-no-celulas-pequenas\/","title":{"rendered":"Valor pron\u00f3stico de la infiltraci\u00f3n tumoral por c\u00e9lulas \u00abnatural killer\u00bb en el c\u00e1ncer de pulm\u00f3n no c\u00e9lulas peque\u00f1as"},"content":{"rendered":"

Tesis doctoral de Villegas Fern\u00e1ndez Francisco Ram\u00f3n <\/strong><\/h2>\n

El c\u00e1ncer de pulm\u00f3n representa un problema de salud p\u00fablica de enorme magnitud. en nuestro pa\u00eds supone el 18% de mortalidad por c\u00e1ncer y el 5% de la mortalidad por cualquier causa. La respuesta inmune es pieza clave en la lucha antitumoral. en este sentido las c\u00e9lulas natural killer (nk) son uno delos principales efectores celulares antitumorales. En este trabajo nos planteamos si la infiltraci\u00f3n tumoral por c\u00e9l.Nk constituye un factor pron\u00f3stico en el c\u00e1ncer de pulm\u00f3n no c\u00e9lulas peque\u00f1as (cpnvp) y puede influir de alguna manera en la supervivencia de dicho c\u00e1ncer, as\u00ed como, que representa comparada con otros factores modificadores del pron\u00f3stico. Se han estudiado 70 pacientes diagnosticados de cpncp sometidos a cirugia como \u00fanica modalidad de tratamiento. se han empleado m\u00e9todos el m\u00e9todo estreptoavodina bitoina peroxidasa para su detecci\u00f3n: se demuestra que la infiltraci\u00f3n tumoral por c\u00e9lulas nk es un factor pron\u00f3stico independiente en cpncp, apreci\u00e1ndose una mayor supervivencia, de forma estad\u00edsticamente significativa, en quellos pacientes con m\u00e1s de 5 c\u00e9l. Nk\/campo respecto aquellos con 5 o menos c\u00e9lulas nk\/campo; punto de corte establecido ha sido la mediana (5 c\u00e9l.Nk), \u00e1rea de campo: 0,173mm2. haciendo una regresi\u00f3n de cox multivariante, incluyendo edad, localizaci\u00f3n endosc\u00f3pica, histolog\u00eda, tama\u00f1o y tnm patol\u00f3gico se observa que el riesgo de morir es 2,32 veces mayor en los pacientes con nk\/campo. Las variables asociadas a un peor pron\u00f3stico, con valor estadisticamente significativo son la localizaci\u00f3n radiol\u00f3gica en l\u00f3bulo inferior derecho, la extensi\u00f3n ganglionar n2 y la elevaci\u00f3n de alt (alaninaaminotransferasa). los resultados obtenidos en este estudio sugieren que cualquier medida destinada a mejorar la respuesta inmunol\u00f3gica de las c\u00e9lulas nk podr\u00eda favorecer una mejora en el pron\u00f3stico del cpncp.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abValor pron\u00f3stico de la infiltraci\u00f3n tumoral por c\u00e9lulas \u00abnatural killer\u00bb en el c\u00e1ncer de pulm\u00f3n no c\u00e9lulas peque\u00f1as<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico de la infiltraci\u00f3n tumoral por c\u00e9lulas \u00abnatural killer\u00bb en el c\u00e1ncer de pulm\u00f3n no c\u00e9lulas peque\u00f1as <\/li>\n
  • Autor:<\/strong>\u00a0 Villegas Fern\u00e1ndez Francisco Ram\u00f3n <\/li>\n
  • Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 03\/12\/2003<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Luis Callol Sanchez<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Jos\u00e9 Luis Alvarez sala walther <\/li>\n
        • Fernando S\u00e1nchez gasc\u00f3n (vocal)<\/li>\n
        • Jos\u00e9 Villamor leon (vocal)<\/li>\n
        • rodrigo Jim\u00e9nez Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Villegas Fern\u00e1ndez Francisco Ram\u00f3n El c\u00e1ncer de pulm\u00f3n representa un problema de salud p\u00fablica de enorme magnitud. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[7468,6075,8307,78382,60803,78381],"class_list":["post-27264","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-fernando-sanchez-gascon","tag-jose-luis-alvarez-sala-walther","tag-jose-villamor-leon","tag-luis-callol-sanchez","tag-rodrigo-jimenez-garcia","tag-villegas-fernandez-francisco-ramon"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27264"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27264\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27264"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27264"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}