{"id":27312,"date":"2003-04-12T00:00:00","date_gmt":"2003-04-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-citoliticos-de-los-linfocitos-t-citotoxicos-perforina-granzimas-granulisina-e-induccion-de-fasl\/"},"modified":"2003-04-12T00:00:00","modified_gmt":"2003-04-12T00:00:00","slug":"mecanismos-citoliticos-de-los-linfocitos-t-citotoxicos-perforina-granzimas-granulisina-e-induccion-de-fasl","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/mecanismos-citoliticos-de-los-linfocitos-t-citotoxicos-perforina-granzimas-granulisina-e-induccion-de-fasl\/","title":{"rendered":"Mecanismos citoliticos de los linfocitos t citotoxicos: perforina\/granzimas, granulisina e inducci\u00f3n de fasl"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Julian Pardo Jimeno <\/strong><\/h2>\n<p>Los linfocitos citot\u00f3xicos son las c\u00e9lulas del sistem inmune encargadas de eliminar c\u00e9lulas tumorales o infectadas por virus. Los linfocitos citot\u00f3xicos m\u00e1s importantes son los linfocitos t citot\u00f3xicos y las c\u00e9lulas nk. Estas c\u00e9lulas inducen la muerte de la c\u00e9lula tumoral o infectada por virus a trav\u00e9s de dos mecanismos principales; el mecanismo de exocitosis granular dentro del cual se encuentra el sistema perforina\/granzimas y la granulisina, y el sistema de receptores mortales, de los cuales fas\/fasl y dr5\/apo2l_trail son los dos m\u00e1s importantes.  en este trabajo se han estudiado las v\u00edas de transducci\u00f3n de se\u00f1al implicadas en la inducci\u00f3n del ligando de fas y en la regulaci\u00f3n del mecanismo de exocitosis granular tras la activaci\u00f3n del complejo tcr\/cd3. Asimismo, se ha analizado el papel del sistema perforina\/granzimas en la eliminaci\u00f3n de c\u00e9lulas tumorales in vivo, as\u00ed como el mecanismo a trav\u00e9s del cual induce apoptosis. Por \u00faltimo, se ha estudiado el mecanismo de apoptosis inducida por la granulisina sobre c\u00e9lulas jurkat.  para analizar la expresi\u00f3n de fasl y la regulaci\u00f3n de la exocitosis granular se han realizado ensayos de citoxicidad utilizando clones de ctl e inhibidores espec\u00edficos de diferentes quinasas y se han realizado trasfecciones de una l\u00ednea de ctl (para estudiar la exocitosis granular) y de la leucemia humana t jurkat (para estudiar la inducci\u00f3n de fasl) con mutantes constitutivamente activos o dominante negativos de pi3k y pkc, junto con una construcci\u00f3n de fasl-luciferasa. Se ha observado que la pi3k, las isoformas theta y epsilon de la familia de las pkc y las mapk erk y p38 mapk se encuentran implicadas en la expresi\u00f3n de fasl, mientras que isoformas cl\u00e1sicas de las pkc, como la alpha y la mapk erk regulan la exocitosis granular.  para estudiar el papel fisiol\u00f3gico del sistema perforina\/granzimas se han utilizado ratones c57bl\/6, de fenotipo silvestre o los siguientes ratones ko:<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos citoliticos de los linfocitos t citotoxicos: perforina\/granzimas, granulisina e inducci\u00f3n de fasl<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos citoliticos de los linfocitos t citotoxicos: perforina\/granzimas, granulisina e inducci\u00f3n de fasl <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Julian Pardo Jimeno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Anel Bernal Luis Alberto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andres Pi\u00f1eiro anton <\/li>\n<li>ram\u00f3n Regueiro jose (vocal)<\/li>\n<li>Manuel Izquierdo (vocal)<\/li>\n<li>abelardo L\u00f3pez rivas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Julian Pardo Jimeno Los linfocitos citot\u00f3xicos son las c\u00e9lulas del sistem inmune encargadas de eliminar c\u00e9lulas tumorales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[13610],"tags":[1980,51636,38046,78474,78475,51637],"class_list":["post-27312","post","type-post","status-publish","format-standard","hentry","category-zaragoza","tag-abelardo-lopez-rivas","tag-andres-pineiro-anton","tag-anel-bernal-luis-alberto","tag-julian-pardo-jimeno","tag-manuel-izquierdo","tag-ramon-regueiro-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27312"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27312\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}