{"id":27338,"date":"2003-05-12T00:00:00","date_gmt":"2003-05-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-de-la-hiperglucemia-en-la-produccion-de-apoptosis-de-celulas-beta-pancreaticas-de-roedores\/"},"modified":"2003-05-12T00:00:00","modified_gmt":"2003-05-12T00:00:00","slug":"implicaciones-de-la-hiperglucemia-en-la-produccion-de-apoptosis-de-celulas-beta-pancreaticas-de-roedores","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cadiz\/implicaciones-de-la-hiperglucemia-en-la-produccion-de-apoptosis-de-celulas-beta-pancreaticas-de-roedores\/","title":{"rendered":"Implicaciones de la hiperglucemia en la producci\u00f3n de apoptosis de c\u00e9lulas beta pancre\u00e1ticas de roedores"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel Mellado Gil <\/strong><\/h2>\n<p>Introducci\u00f3n  la apoptosis participa en el proceso de destrucci\u00f3n de la c\u00e9lula beta que acontece en la diabetes. Un mejor conocimiento de este fen\u00f3meno es esencial para el desarrollo de estrategias terap\u00e9uticas dirigidas a la prevenci\u00f3n de la p\u00e9rdida de la c\u00e9lula beta y de la diabetes.  objetivos  1,- evaluar el efecto de la alta concentraci\u00f3n de glucosa sobre la apoptosis de las c\u00e9lulas de islotes pancre\u00e1ticos inducida por estrptozotocina y citoquinas proinflamatorias.  2,- valorar las modificaciones en la expresi\u00f3n de fas y las prote\u00ednas antiapopt\u00f3ticas bcl-2 y bcl-xl en presencia de alta concentraci\u00f3n de glucosa y agentes inductores de apoptosis  m\u00e9todos  islotes procedentes de ratas wistar se cultivaron en rpmi con 5.5 \u00f3 24.4 mm de glucosa y se trataron con interleuquina-beta, sola o combinada con factor de necrosis tumoral-alfa e interfer\u00f3n-gamma, y cone streptozotocina. la detecci\u00f3n y cuantificaci\u00f3n de apoptosis se realiz\u00f3 por el m\u00e9todo tunel y la expresi\u00f3n de prote\u00ednas se valor\u00f3 mediante western-blot al final de los tratamientos.  resultados  los islotes tratados con una combinaci\u00f3n de citoquinas (interleuquina-1beta, factor de necrosis tumoral-alfa e interfer\u00f3n-gamma) mostraron un aumento significativo de la apoptosis cuando fueron incubados con una alta concentraci\u00f3n de glucosa (24.4 mm comparado con los no tratados en la misma concentraci\u00f3n de glucosa (p menor 0,01) o islotes incubados en 5.5 mm de glucosa y citoquinas (p menor 0,05). Il-1beta sola no indujo un aumento significativo en la apoptosis de los islotes cultivados con concentraciones normales o altas de glucosa. La estreptozotocina aument\u00f3 significativamente la apoptosis en los islotes cultivados con 24.4 mm de glucosa comparada con los no tratados con la misma concentraci\u00f3n de glucosa (p menor 0,05). La alta concentraci\u00f3n de glucosa indujo un aumento en la expresi\u00f3n de fas en las c\u00e9lulas del islote (p menor 0,05) que se man<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones de la hiperglucemia en la producci\u00f3n de apoptosis de c\u00e9lulas beta pancre\u00e1ticas de roedores<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones de la hiperglucemia en la producci\u00f3n de apoptosis de c\u00e9lulas beta pancre\u00e1ticas de roedores <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel Mellado Gil <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Aguilar Diosdado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: antonino Sara albarran <\/li>\n<li>Jos\u00e9 Antonio Gir\u00f3n gonz\u00e1lez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Brieva romero (vocal)<\/li>\n<li> Cuesta mu\u00f1oz Antonio  Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel Mellado Gil Introducci\u00f3n la apoptosis participa en el proceso de destrucci\u00f3n de la c\u00e9lula beta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1506],"tags":[78525,31715,7334,10865,78524,1640],"class_list":["post-27338","post","type-post","status-publish","format-standard","hentry","category-cadiz","tag-antonino-sara-albarran","tag-cuesta-munoz-antonio-luis","tag-jose-antonio-brieva-romero","tag-jose-antonio-giron-gonzalez","tag-jose-manuel-mellado-gil","tag-manuel-aguilar-diosdado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27338"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27338\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}