{"id":27434,"date":"2003-10-12T00:00:00","date_gmt":"2003-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-genes-bcl-2-reguladores-de-apoptosis-en-epitelio-tubular-renal-de-rata-en-respuesta-a-isquemia-reperfusion\/"},"modified":"2003-10-12T00:00:00","modified_gmt":"2003-10-12T00:00:00","slug":"expresion-de-genes-bcl-2-reguladores-de-apoptosis-en-epitelio-tubular-renal-de-rata-en-respuesta-a-isquemia-reperfusion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/a-coruna\/expresion-de-genes-bcl-2-reguladores-de-apoptosis-en-epitelio-tubular-renal-de-rata-en-respuesta-a-isquemia-reperfusion\/","title":{"rendered":"Expresi\u00f3n de genes bcl-2, reguladores de apoptosis, en epitelio tubular renal de rata en respuesta a isquemia-reperfusi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Vald\u00e9s Ca\u00f1edo <\/strong><\/h2>\n<p>Se ha estudiado la expresi\u00f3n de arn mensajero de bcl-2, bcl-xl, bcl-xs y bax en los t\u00edtulos contorneados proximal, parte recta del t\u00fabulo proximal, porci\u00f3n gruesa ascendente del asa de heale y t\u00fabulo contorneado distal del ri\u00f1\u00f3n de ratas wistar sometidas a microdisecci\u00f3n nefronal tras un periodo de isquemia de 30 minutos, con reperfusi\u00f3n de 0,3,6,24,48,96,144 y 216 horas de respectivamente. Los resultados obtenidos en cada segmento y en cada tiempo de reperfusi\u00f3n se compararon con los obtenidos en un grupo control constituido por ratas sometidas a simulaci\u00f3n de isquemia y sacrificadas en periodos coincidentes con los de reperfusi\u00f3n del grupo isquemico. En total se utilizaron 96 ri\u00f1ones procedentes de 48 ratas, 3 por cada grupo, isqu\u00e9mico o control en cada tiempo de reperfusi\u00f3n o de postsimulaci\u00f3n respectivamente.  el material para estudio se obtuvo tras la extracci\u00f3n renal mediante su corte sagital y obtenci\u00f3n de cu\u00f1as corticales o medulares, incubadas con colagenasas y microdiseccionadas en placa de petri para la identificaci\u00f3n y obtenci\u00f3n de los segmentos tubulares objeto del estudio. La expresi\u00f3n del arn mensajero en cada caso se analiz\u00f3 y cuantific\u00f3 tras su extracci\u00f3n del material tubular y amplificaci\u00f3n con rt-pcr. En total se estudiaron 384 muestras correspondientes a la expresi\u00f3n de bcl-2, bcl-xl, bcl-xs y bax en los cuatro segmentos tubulares referidos anteriormente.  los resultados demuestran que hay sobrexpresi\u00f3n de genes bcl-2 en el epitelio tubular de rata tanto en fases precoces como en fases tard\u00edas de reperfusi\u00f3n lo que sugiere la importancia que tienen estos genes en la regulaci\u00f3n de la apoptosis a lo largo de todo el ciclo de lesi\u00f3n y reparaci\u00f3n tubular tras isquemia. La isquemia y la reperfusi\u00f3n parecen actuar como est\u00edmulos hasta cierto punto independientes para la expresi\u00f3n g\u00e9nica, ya que se encontr\u00f3 sobrexpresi\u00f3n de bcl-2 en la parte gruesa de la rama del asa de henle y en menor<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de genes bcl-2, reguladores de apoptosis, en epitelio tubular renal de rata en respuesta a isquemia-reperfusi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de genes bcl-2, reguladores de apoptosis, en epitelio tubular renal de rata en respuesta a isquemia-reperfusi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Vald\u00e9s Ca\u00f1edo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pasaro Mendez Eduardo Jose<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Rodriguez perez <\/li>\n<li>d\u00e1maso Sanz guajardo (vocal)<\/li>\n<li>alfonso Castro beiras (vocal)<\/li>\n<li>eduardo V\u00e1zquez martul (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Vald\u00e9s Ca\u00f1edo Se ha estudiado la expresi\u00f3n de arn mensajero de bcl-2, bcl-xl, bcl-xs y bax [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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