{"id":27458,"date":"2003-11-12T00:00:00","date_gmt":"2003-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-micro-y-nanoparta%c2%adculas-polimericas-para-la-administracion-de-vacunas-por-distintas-va%c2%adas-mucosas\/"},"modified":"2003-11-12T00:00:00","modified_gmt":"2003-11-12T00:00:00","slug":"desarrollo-de-micro-y-nanoparta%c2%adculas-polimericas-para-la-administracion-de-vacunas-por-distintas-va%c2%adas-mucosas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/desarrollo-de-micro-y-nanoparta%c2%adculas-polimericas-para-la-administracion-de-vacunas-por-distintas-va%c2%adas-mucosas\/","title":{"rendered":"Desarrollo de micro y nanopart\u00edculas polim\u00e9ricas para la administraci\u00f3n de vacunas por distintas v\u00edas mucosas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ibon Gutierro Aduriz <\/strong><\/h2>\n<p>La microencapsulaci\u00f3n de p\u00e9ptidos antig\u00e9nicos representa una ventaja competitiva frente al uso de los mismos ant\u00edgenos adminstrados en forma libre por v\u00edas parenterales y mucosas.  en la presente memoria experimental se ha opitmizado el m\u00e9todo de elaboraci\u00f3n de part\u00edculas de plga nanom\u00e9tricas ( de 200 nm y 500 nm) y se ha realizado un estudio comparativo de las caracter\u00edsticas in vitro de las part\u00edculas obtenidas frente a las part\u00edculas de plga de 1 um. Los resultados demuestran que las part\u00edculas m\u00e1s peque\u00f1as originan menores rendimientos de encapsulaci\u00f3n, aunque estos nunca son menores del 65%. No obstante, no se observan diferencias significativas en las caracter\u00edsticas in vitro de las part\u00edculas de diferentes tama\u00f1os obtenidas, puesto que los perfiles de liberaci\u00f3n y los potenciales zeta de las mismas son equivalentes para todo el rango de tama\u00f1os estudiado. adem\u00e1s, la bsa permanece en todos los casos estable frente al proceso de encapsulaci\u00f3n (tal y como se ha determinado mediante la t\u00e9cnica de sds-page) y se encuentra en forma de dispersi\u00f3n s\u00f3lida en el interior de la matriz polim\u00e9rica de plga, sin establecer interacciones significativas con el pol\u00edmero que la encapsula (determinado por calorimetr\u00eda diferencial de barrido). Una vez caracterizadas las part\u00edculas in vitro se procedi\u00f3 a determinar sus propiedades inmunog\u00e9nicas.  los resultados obtenidos por las v\u00edas subcut\u00e1nea, oral e intranasal demuestran que la administraci\u00f3n de part\u00edculas de 1 um de plga cargadas con bsa originan respuestas sist\u00e9micas de igg significativamente superiores que las que se obtienen con part\u00edculas nanom\u00e9tricas o con el ant\u00edgeno libre. Asimismo, todas las formulaciones de part\u00edculas estimulan la formaci\u00f3n de una respuesta combinada de igg2a e igg1, cuya ratio es significativamente superior al que se obtiene con la administraci\u00f3n del ant\u00edgeno libre, o del ant\u00edgeno adsorbido al hidr\u00f3xido de aluminio. Todas las f<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de micro y nanopart\u00edculas polim\u00e9ricas para la administraci\u00f3n de vacunas por distintas v\u00edas mucosas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de micro y nanopart\u00edculas polim\u00e9ricas para la administraci\u00f3n de vacunas por distintas v\u00edas mucosas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ibon Gutierro Aduriz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge  Antonio Guisantes del barco <\/li>\n<li>Jos\u00e9 Martinez lanao (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Alonso fernandez (vocal)<\/li>\n<li>Manuel Guzm\u00e1n navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ibon Gutierro Aduriz La microencapsulaci\u00f3n de p\u00e9ptidos antig\u00e9nicos representa una ventaja competitiva frente al uso de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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