{"id":27480,"date":"2003-12-12T00:00:00","date_gmt":"2003-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anticuerpos-antiprotrombina-y-resistencia-adquirida-a-la-protea%c2%adna-c-activada-en-el-sa%c2%adndrome-antifosfolipa%c2%addico\/"},"modified":"2003-12-12T00:00:00","modified_gmt":"2003-12-12T00:00:00","slug":"anticuerpos-antiprotrombina-y-resistencia-adquirida-a-la-protea%c2%adna-c-activada-en-el-sa%c2%adndrome-antifosfolipa%c2%addico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/anticuerpos-antiprotrombina-y-resistencia-adquirida-a-la-protea%c2%adna-c-activada-en-el-sa%c2%adndrome-antifosfolipa%c2%addico\/","title":{"rendered":"Anticuerpos antiprotrombina y resistencia adquirida a la prote\u00edna c activada en el s\u00edndrome antifosfolip\u00eddico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mu\u00f1oz Rodr\u00edguez Francisco Jose <\/strong><\/h2>\n<p>En la tesis doctoral se establecen tres objetivos fundamentales: profundizar en el conocimiento de las caracter\u00edsticas cl\u00ednicas del s\u00edndrome antifosfolip\u00eddico, estudiar el papel de los anticuerpos antiprotrombina en su fisiopatolog\u00eda y analizar la resistencia adquirida a la acci\u00f3n de la prote\u00edna c activada como un posible mecanismo de las trombosis asociadas a los anticuerpos antifosfolip\u00eddicos. Para respoder a estos objetivos se dise\u00f1aron tres estudios.  el primero fue un estudio cl\u00ednico en el que se analizaron las caracter\u00edsticas cl\u00ednicas y evolutivas de 100 pacientes diagnosticados de s\u00edndrome antifosfolip\u00eddico con una mediana del tiempo de seguimiento de 49 meses.  se observ\u00f3 que los pacientes con antecedentes de trombosis tienen un alto riesgo de recurrencias y que la anticoagulaci\u00f3n oral administrada de forma indefinida es la mejor profilaxis; adem\u00e1s, la administraci\u00f3n de tratamiento profil\u00e1ctico durante el embarazo de las pacientes con el mencionado s\u00edndrome reduce de forma considerable el riesgo de abortos o p\u00e9rdidas fetales.  en el segundo estudio se estandariz\u00f3 una t\u00e9cnica de elisa para la detecci\u00f3n de los anticuerpos antiprotrombina y se estudi\u00f3 su presencia en una serie de 177 pacientes con s\u00edndrome antifosfolip\u00eddico primario o lupus eritematoso sist\u00e9mico. Se obtuvo una preValencia global del 47%, significativamente superior a la observada en el grupo control formado por 87 voluntarios sanos (5%). Adem\u00e1s en pacientes con lupus eritematoso sist\u00e9mico su isotipo igg constituye un factor de riesgo independiente para el desarrollo de trombosis. Finalmente, en el tercer estudio se analiz\u00f3 la resistencia adquirida a la acci\u00f3n de la prote\u00edna c activada, aquella que no era debida a la presencia del factor v leiden, en 103 pacientes con lupus eritematoso sist\u00e9mico y en 103 voluntarios sanos. Primero se observ\u00f3 que la presencia del factor v leiden es baja y similar a la poblaci\u00f3n general (4%).  la re<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anticuerpos antiprotrombina y resistencia adquirida a la prote\u00edna c activada en el s\u00edndrome antifosfolip\u00eddico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anticuerpos antiprotrombina y resistencia adquirida a la prote\u00edna c activada en el s\u00edndrome antifosfolip\u00eddico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mu\u00f1oz Rodr\u00edguez Francisco Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Font Franco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>antoni Vidaller palacin (vocal)<\/li>\n<li>vicente Fonollosa pla (vocal)<\/li>\n<li>carmen Herrero mateu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mu\u00f1oz Rodr\u00edguez Francisco Jose En la tesis doctoral se establecen tres objetivos fundamentales: profundizar en el conocimiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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