{"id":27534,"date":"2003-12-12T00:00:00","date_gmt":"2003-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-sobre-la-funcion-vascular-de-l-carnitina-y-su-derivado-acilado-propionil-l-carnitina\/"},"modified":"2003-12-12T00:00:00","modified_gmt":"2003-12-12T00:00:00","slug":"efectos-sobre-la-funcion-vascular-de-l-carnitina-y-su-derivado-acilado-propionil-l-carnitina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/efectos-sobre-la-funcion-vascular-de-l-carnitina-y-su-derivado-acilado-propionil-l-carnitina\/","title":{"rendered":"Efectos sobre la funci\u00f3n vascular de l-carnitina y su derivado acilado propionil-l-carnitina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Bueno Borrego Rosario M. <\/strong><\/h2>\n<p>L-carnitina es un derivado amino\u00e1cido cuya principal funci\u00f3n biol\u00f3gica es transportar \u00e1cidos grasos de cadena larga al interior de la mitocondria para producir energ\u00eda en el ciclo de krebs. Uno de sus derivados m\u00e1s potentes es el \u00e9ster de cadena corta propionil-l-carnitina. L-carnitina se emplea a nivel cardiovascular como coadyuvante en el tratamiento de s\u00edntomas relacionados con la enfermedad, salvo en aquellos casos en los que la patolog\u00eda sea consecuencia de un d\u00e9ficit de este derivado amino\u00e1cido en los que se utiliza como principal agente terap\u00e9utico. En el caso de la enfermedad arterial perif\u00e9rica es el derivado propionilico el que est\u00e1 siendo empleado incluso de forma m\u00e1s efectiva que l-carnitina. Concretamente se est\u00e1 utilizando en el tratamiento de pacientes con claudicaci\u00f3n intermitente los cuales mejoran su capacidad de caminar.  debido a su empleo a nivel cardiovascular seleccionamos ambos mol\u00e9culas para analizar su efecto vasodilatador en ratas gen\u00e9ticamente hipertensas. para ello realizamos dos estudios; uno del efecto in vitro y otro del cr\u00f3nico.  en el estudio in vitro vimos como en el efecto relajante de ambos f\u00e1rmacos en anillos de aorta era dependiente de endotelio y significativamente mayor en animales hipertensos que en normotensos. En la acci\u00f3n de ambos f\u00e1rmacos est\u00e1n implicados el no principalmente, sin descartar la participaci\u00f3n de pgi2 y factores vasoconstrictores derivados de cox. Del mismo modo parece que l-carnitina podr\u00eda estar implicada en una menor generaci\u00f3n de radicales libres derivados de ox\u00edgeno.  la administraci\u00f3n cr\u00f3nica de los dos derivados amino\u00e1cidos mejor\u00f3 la funci\u00f3n endotelial y vascular tanto en arterias de conductancia como en las de resistencia en animales hipertensos sin provocar cambios apreciables en los valores de presi\u00f3n arterial y frecuencia cardiaca. Este efecto fue debido a un aumento de la participaci\u00f3n del no siendo en el caso  de propionil-l-carn<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos sobre la funci\u00f3n vascular de l-carnitina y su derivado acilado propionil-l-carnitina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos sobre la funci\u00f3n vascular de l-carnitina y su derivado acilado propionil-l-carnitina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Bueno Borrego Rosario M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Herrera Gonzalez M. Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: elisa Marhuenda requena <\/li>\n<li> Sa\u00e9nz rodr\u00edguez M\u00aa teresa (vocal)<\/li>\n<li>Juan  Manuel Duarte p\u00e9rez (vocal)<\/li>\n<li>Francisco P\u00e9rez vizca\u00edno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bueno Borrego Rosario M. L-carnitina es un derivado amino\u00e1cido cuya principal funci\u00f3n biol\u00f3gica es transportar \u00e1cidos grasos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10715],"tags":[78983,11334,62502,78984,43504,78985],"class_list":["post-27534","post","type-post","status-publish","format-standard","hentry","category-sevilla","tag-bueno-borrego-rosario-m","tag-elisa-marhuenda-requena","tag-francisco-perez-vizcaino","tag-herrera-gonzalez-m-dolores","tag-juan-manuel-duarte-perez","tag-saenz-rodriguez-ma-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27534"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27534\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}