{"id":27539,"date":"2003-12-12T00:00:00","date_gmt":"2003-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-irradiacion-cerebral-sobre-el-aprendizaje-en-ratas-macho\/"},"modified":"2003-12-12T00:00:00","modified_gmt":"2003-12-12T00:00:00","slug":"efectos-de-la-irradiacion-cerebral-sobre-el-aprendizaje-en-ratas-macho","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-irradiacion-cerebral-sobre-el-aprendizaje-en-ratas-macho\/","title":{"rendered":"Efectos de la irradiaci\u00f3n cerebral sobre el aprendizaje en ratas macho"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  L\u00f3pez Mu\u00f1oz Enrique Alejandro <\/strong><\/h2>\n<p>Introducci\u00f3n  en la pr\u00e1ctica cl\u00ednica diaria, pacientes afectos de neopl\u00e1sias cerebrales se ven sometidos a irradiaci\u00f3n cerebral con intenci\u00f3n curativa o paliativa. este tipo de terapias puede ocasionar alteraciones en las funciones cognitivas y los estudios efectuados en relaci\u00f3n  con la memoria y el aprendizaje no son del todo homog\u00e9neos.  introducci\u00f3n te\u00f3rica  cuatro variables cr\u00edticas con papel modulador, son la edad, tiempo, dosis y volumen cerebral engolobado. Dos patrones de lesi\u00f3n histol\u00f3gica, las alteraciones de la barrera hematoencef\u00e1lica, y el da\u00f1o en la vaina de mielina.  objetivos  \u00abestudiar el efecto de la irradiaci\u00f3n cerebral sobre las conductas de aprendizaje y memoria, mediante los paradigmas de evitaci\u00f3n condicionada y discriminaci\u00f3n simple, empleando diferentes esquemas de fraccionamiento de la dosis total\u00bb.  hip\u00f3tesis  \u00abla exposici\u00f3n cerebral a radiaciones ionizantes con diferentes dosis acumuladas (20,30 y 59 gy), puede generar d\u00e9ficits cognitivos, cuya manifestaci\u00f3n cl\u00ednica podr\u00eda traducirse en deterioros en el nivel de aprendizaje a medio y largo plazo\u00bb.  material y m\u00e9todos  136 ratas macho, wistar, 4 meses de edad. El aparato de irradaici\u00f3n cerebral fue una unidad theratron 780 con fuente natural de co60. La evaluaci\u00f3n conductual se realiz\u00f3 medainte la caja de escape evitaci\u00f3n de dos sentidos, paradigmas de evitaci\u00f3n condicionada de dos sentidos y laberinto en y, paradigma de discriminaci\u00f3n simple. La valoraci\u00f3n histol\u00f3gica se realiz\u00f3 mediante t\u00e9cnica cuantitativa y cualitatitva.  experimento 1  106 ratas macho, 1 grupo control, anestesia, 20,30 y 50 gy. La valoraci\u00f3n conductual fue peri\u00f3dica, al 1\u00c2\u00ba mes y trimestralmente hasta el 9\u00c2\u00ba mes desde la irradiaci\u00f3n cerebral. Todos los aniamles progresaron en el aprendizaje con un mayor n\u00famero de evitaciones con la repetici\u00f3n de las evaluaci\u00f3nes, excepto 50 gy. La comparaci\u00f3n entre el 5\u00c2\u00ba d\u00eda (mes 1) con respectoa l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la irradiaci\u00f3n cerebral sobre el aprendizaje en ratas macho<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la irradiaci\u00f3n cerebral sobre el aprendizaje en ratas macho <\/li>\n<li><strong>Autor:<\/strong>\u00a0  L\u00f3pez Mu\u00f1oz Enrique Alejandro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mi\u00f1arro L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Sim\u00f3n p\u00e9rez <\/li>\n<li>Miguel Garcia navarro (vocal)<\/li>\n<li>Emilio Ambrosio flores (vocal)<\/li>\n<li>ignacio Morgado bernal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de L\u00f3pez Mu\u00f1oz Enrique Alejandro Introducci\u00f3n en la pr\u00e1ctica cl\u00ednica diaria, pacientes afectos de neopl\u00e1sias cerebrales se ven [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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