{"id":27545,"date":"2003-12-12T00:00:00","date_gmt":"2003-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influence-of-simulated-intestinal-media-on-permeability-of-a-poorly-soluble-compound-across-caco-2-cell-monolayes\/"},"modified":"2003-12-12T00:00:00","modified_gmt":"2003-12-12T00:00:00","slug":"influence-of-simulated-intestinal-media-on-permeability-of-a-poorly-soluble-compound-across-caco-2-cell-monolayes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/influence-of-simulated-intestinal-media-on-permeability-of-a-poorly-soluble-compound-across-caco-2-cell-monolayes\/","title":{"rendered":"Influence of simulated intestinal media on permeability of a poorly soluble compound across caco-2 cell monolayes"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ilardia Arana David Javier <\/strong><\/h2>\n<p>Los f\u00e1rmacos de baja solubilidad en agua, clase ii en el sistema de clasificaci\u00f3n biofarmac\u00e9utica, requieren del empleo de medios intestinales simulados (mis) para una buena predicci\u00f3n in vitro de la solubilidad. Estos mis aumentan la solubilidad de esta clase de f\u00e1rmacos y, por ello, tambi\u00e9n son potencialmente \u00fatiles para estudios in vitro de la permeabilidad. El objetivo de esta tesis ha sido el empleo de mis (consistentes en combinaciones fisiol\u00f3gicas) en la estimaci\u00f3n de la permeabilidad del estradio (solubilidad 3.9 ug\/ml, log p 3.8) en monacapas de c\u00e9lulas caco-2.  los amf\u00edfilos presentes en los mis forma micelas mixtas alta concentraci\u00f3n y que, al ser diluidos, las micelas aumentan de tama\u00f1o y aparecen ves\u00edculas. la solubilidad del estradiol aumenta en funci\u00f3n de la concentraci\u00f3n total de amf\u00edfilo. Por el contrario, al permeabilidad disminuye probablemente debido a un aumento del reparto del f\u00e1rmaco hacia los agregados y reducci\u00f3n de la concentraci\u00f3n celular. La integridad celular se mantuvo en el medio sal biliar y fosfol\u00edpido lo que sugiere su selecci\u00f3n para estudios en c\u00e9lulas caco-2.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influence of simulated intestinal media on permeability of a poorly soluble compound across caco-2 cell monolayes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influence of simulated intestinal media on permeability of a poorly soluble compound across caco-2 cell monolayes <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ilardia Arana David Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Rabasco alvarez <\/li>\n<li>cecilia Fernandez lastra (vocal)<\/li>\n<li>eduardo Mari\u00f1o hernandez (vocal)<\/li>\n<li>anette M\u00ed\u00bcllertz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ilardia Arana David Javier Los f\u00e1rmacos de baja solubilidad en agua, clase ii en el sistema de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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