{"id":27554,"date":"2003-12-12T00:00:00","date_gmt":"2003-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/human-pharmacology-of-ayahuasca\/"},"modified":"2003-12-12T00:00:00","modified_gmt":"2003-12-12T00:00:00","slug":"human-pharmacology-of-ayahuasca","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/human-pharmacology-of-ayahuasca\/","title":{"rendered":"Human pharmacology of ayahuasca"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jordi Riba Serrano <\/strong><\/h2>\n<p>La ayahuasca es una bebida psicotr\u00f3pica obtenida de las plantas banisteriopsis caapi y psychotria viridis, que ha sido utilizada desde hace siglos en las cuencas de los r\u00edos amazonas y oronoco con finalidades m\u00e1gico-religiosas y en la medicina tradicional de estas \u00e1reas geogr\u00e1ficas. La bebida contiene alcaloides que muestran actividad inhibidora del enzima monoamino oxidasa o mao (harmina, harmalina y tetrahidroharmina) y un compuesto alucin\u00f3geno (la n,n-dimetiltriptamina o dmt) que es inactivo por v\u00eda oral en ausencia de los anteriores. El consumo de ayahuasca se ha ido popularizando lentamente en europa desde principios de la d\u00e9cada a los 90. Dada la escasa informaci\u00f3n existente sobre los efectos de la ayahuasca en humanos, se llevaron a cabo dos estudios cl\u00ednicos con voluntarios sanos a los que se administraron distintas dosis de ayahuasca liofilizada y encapsulada.  en un primer estudio piloto se administraron en orde creciene un placebo y tres dosis de ayahuasca correspondientes a 0.50, 0.75 y 1,. Mg dmt\/kg peso a 6 voluntarios sanos en condiciones de simple ciego. En el estudio final se administraron de forma aleatorizada y balanceada un placebo y dos dosis de ayahuasca correspondientes a 0.6 y 0.85 mg dmt\/kg peso a 18 voluntarios sanos en condiciones de doble ciego. Las variables estudiadas incluyeron medidas de efectos subjetivos, medidas cardiovasculares, farmacocin\u00e9tica, niveles dematabolitos de neurontrasmisores en orina, resigros de electroencefalograf\u00eda (eeg), potencias evocados (supresi\u00f3n del potencial auditivo p50) y electromiograf\u00eda (supresi\u00f3n del reflejo de sobresalto).  la ayahuasca produjo efectos subjetivos de activaci\u00f3n, bienestar y euforia, cambios en la percepci\u00f3n som\u00e1tica y visual y cambios en el contenido y velocidad del pensamiento. Los efectos subjetivos m\u00e1ximos se observaron a los 60-120 minutos y desaparecieron a las 4-6 horas postadministraci\u00f3n. los efectos caridovascualres fueron moderado<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Human pharmacology of ayahuasca<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Human pharmacology of ayahuasca <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jordi Riba Serrano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel J Barbanoj Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: albert Badia sancho <\/li>\n<li>miquel Casas brugue (vocal)<\/li>\n<li>thomas Muente (vocal)<\/li>\n<li>Francisco Javier Galiana Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jordi Riba Serrano La ayahuasca es una bebida psicotr\u00f3pica obtenida de las plantas banisteriopsis caapi y psychotria [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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