{"id":27558,"date":"2003-12-12T00:00:00","date_gmt":"2003-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-protea%c2%adna-ns1-del-virus-de-la-gripe-actividades-nucleares-y-citosolicas-e-implicaciones-en-la-patogenesis-viral\/"},"modified":"2003-12-12T00:00:00","modified_gmt":"2003-12-12T00:00:00","slug":"la-protea%c2%adna-ns1-del-virus-de-la-gripe-actividades-nucleares-y-citosolicas-e-implicaciones-en-la-patogenesis-viral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-protea%c2%adna-ns1-del-virus-de-la-gripe-actividades-nucleares-y-citosolicas-e-implicaciones-en-la-patogenesis-viral\/","title":{"rendered":"La prote\u00edna ns1 del virus de la gripe: actividades nucleares y citos\u00f3licas e implicaciones en la patog\u00e9nesis viral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana M. Falc\u00f3n Escalona <\/strong><\/h2>\n<p>El genoma del virus de la gripe tipo a est\u00e1 compuesto por ocho segmentos de rna de cadena sencilla y polaridad negativa que codifican un total de diez prote\u00ednas. La prote\u00edna ns1 es una prote\u00edna no estructural que se localiza en el n\u00facleo de las c\u00e9lulas infectadas a tiempos tempranos post-infecci\u00f3n y tambi\u00e9n se encuentra en el citosol a tiempos tard\u00edos post-infecci\u00f3n. la prote\u00edna no estructural ns1 es una prote\u00edna de uni\u00f3n a rna importante para la inhibici\u00f3n de la respuesta a interfer\u00f3n. Existen evidencias que sugieren que esta prote\u00edna est\u00e1 implicada en la modulaci\u00f3n del splicing de mrna, retenci\u00f3n nuclear de mrnas poli(a) y estimulaci\u00f3n de la traducci\u00f3n de mensajeros virales. Ns1 se encuentra asociada a las rnps virales y podr\u00eda estar implicada en los procesos de transcripci\u00f3n y replicaci\u00f3n viral.  durante el desarrollo de un ensayo de doble-h\u00edbrido en el que se utiliz\u00f3 la prote\u00edna ns1 como cebo, se encontr\u00f3 un clon humano que codifica una prote\u00edna hom\u00f3loga a la prote\u00edna staufen de d.Melanogaste (dmstaufen). Se ha descrito que la prote\u00edna dmstaufen interaccionan con, y localiza determinados mrnas en lugares precisos en el oocito de mosca. El hom\u00f3logo humano a dmstufen, hstaufen, es una prote\u00edna de uni\u00f3n a rna de doble cadena que se encuentra asociada a polisomas y al ret\u00edculo endopl\u00e1smico rugoso. Las prote\u00ednas ns1 y hstaufen interaccionan in vitro cuando son co-expresadas a partir de sus cdnas clonados.  para estudiar las funciones de la prote\u00edna ns1 durante la infecci\u00f3n viral, se han generado virus mutantes puntuales o de delecci\u00f3n de la prote\u00edna ns1. Los virus mutantes de deleci\u00f3n se han rescatado por el sistema ya descrito de cdnas clonados, y los virus mutantes puntuales se han generado por un nuevo sistema de co-transfecci\u00f3n de rnps. Estos virus mutantes puntuales de la prote\u00edna ns1 se han generado co-transfectando rnps purificadas de viriones y una librer\u00eda de rnps del segmento ns mutag<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La prote\u00edna ns1 del virus de la gripe: actividades nucleares y citos\u00f3licas e implicaciones en la patog\u00e9nesis viral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La prote\u00edna ns1 del virus de la gripe: actividades nucleares y citos\u00f3licas e implicaciones en la patog\u00e9nesis viral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana M. Falc\u00f3n Escalona <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Ortin Monton<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Garcia alvarez <\/li>\n<li>Jos\u00e9 Antonio Melero fondevilla (vocal)<\/li>\n<li>Francisco Sobrino castello (vocal)<\/li>\n<li>matilde Salinas aracil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana M. Falc\u00f3n Escalona El genoma del virus de la gripe tipo a est\u00e1 compuesto por ocho [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[79040,14395,14396,14510,14725,17565],"class_list":["post-27558","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-ana-m-falcon-escalona","tag-francisco-sobrino-castello","tag-jose-antonio-melero-fondevilla","tag-juan-antonio-garcia-alvarez","tag-juan-ortin-monton","tag-matilde-salinas-aracil"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27558"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27558\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}