{"id":27612,"date":"2018-03-09T09:19:57","date_gmt":"2018-03-09T09:19:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-una-nueva-fase-fenota%c2%adpica-de-bordetella-pertussis-la-fase-intermedia-bvg-i-y-evaluacion-de-su-posible-papel-durante-la-infeccion-respiratoria\/"},"modified":"2018-03-09T09:19:57","modified_gmt":"2018-03-09T09:19:57","slug":"caracterizacion-de-una-nueva-fase-fenota%c2%adpica-de-bordetella-pertussis-la-fase-intermedia-bvg-i-y-evaluacion-de-su-posible-papel-durante-la-infeccion-respiratoria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/caracterizacion-de-una-nueva-fase-fenota%c2%adpica-de-bordetella-pertussis-la-fase-intermedia-bvg-i-y-evaluacion-de-su-posible-papel-durante-la-infeccion-respiratoria\/","title":{"rendered":"Caracterizaci\u00f3n de una nueva fase fenot\u00edpica de bordetella pertussis, la fase intermedia (bvg i), y evaluaci\u00f3n de su posible papel durante la infecci\u00f3n respiratoria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nuria Vergara Irigaray <\/strong><\/h2>\n<p>Bordetella pertussis es un cocobacilo gram-negativo responsable de la tos ferina, una enfermedad respiratoria aguda exclusiva del ser humano que afecta cada a\u00f1o a m\u00e1s de 250.000 personas en todo el mundo, principalmente ni\u00f1os.  hasta el momento se conoc\u00eda bien la capacidad de b.Pertussis para alternar entre dos fases fenot\u00edpicas o antig\u00e9nicas distintas denominadas fase positiva (bvg +) y negativa (bvg -), en respuesta a est\u00edmulos ambientales qu\u00edmicos o f\u00edsicos (agentes moduladores) captados y procesados por el sistema de dos componentes bvgas. En este trabajo hemos identificado una tercera fase fenot\u00edpica (fase intermedia (bvg i)) y hemos demostrado que las fases bvg i de b.Pertussis y b.Bronchiseptica (una especie estrechamente relacionada con b.Pertussis que no infecta al ser humano) son muy similares. As\u00ed, la transici\u00f3n de b.Pertussis a  la base bvg i se puede inducir mediante mutag\u00e9nesis dirigida (presencia del alelo bvgs-i1 de b.Bronchiseptica) o cultivando el microorganismo en condiciones de semimodulaci\u00f3n, esto es, en presencia de concentraciones intermedias de moduladores o bien por incubaci\u00f3n a 30\u00c2\u00bac.  como b.Bronchiseptica, b.Pertussis genera en su fase bvg i colonias de tama\u00f1o, grado de aplanamiento y actividad hemol\u00edtica intermedias entre las caracter\u00edsticas de las fases bvg+ y bvg- y expresa un polip\u00e9tido de alto peso molecular espec\u00edfico de la fase bvg i denominado bipa. La expresi\u00f3n de bipa es m\u00e1xima en la fase bvg i y est\u00e1 regulada por bvgas a nivel de la transcripci\u00f3n. Sin embargo, las fases bvg i de b.Pertussis y b.Bronchiseptica difieren en el rango de sustancia moduladora que necesitan para inducir la modulaci\u00f3n a la fase bvg i, en el hecho de que b.Bronchiseptica expresa bipa tambi\u00e9n en la fase bvg+ y en el menor peso molecular de bipa de b.Pertussis.  el hecho de que un mutante de b.Pertussis bloqueado en la fase bvg i fuera incapaz de colonizar la tr\u00e1nquea y el pulm\u00f3n del rat\u00f3n demuestr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de una nueva fase fenot\u00edpica de bordetella pertussis, la fase intermedia (bvg i), y evaluaci\u00f3n de su posible papel durante la infecci\u00f3n respiratoria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de una nueva fase fenot\u00edpica de bordetella pertussis, la fase intermedia (bvg i), y evaluaci\u00f3n de su posible papel durante la infecci\u00f3n respiratoria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nuria Vergara Irigaray <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Mart\u00ednez De Tejada De Garaiz\u00e1bal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Rodr\u00edguez burgos <\/li>\n<li>Juan Garc\u00eda lobo (vocal)<\/li>\n<li>ram\u00f3n Luis D\u00edaz Garc\u00eda (vocal)<\/li>\n<li>beatriz Amorena zabalza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nuria Vergara Irigaray Bordetella pertussis es un cocobacilo gram-negativo responsable de la tos ferina, una enfermedad respiratoria [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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