{"id":27652,"date":"2018-03-09T09:20:01","date_gmt":"2018-03-09T09:20:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-de-la-regulacion-y-del-contenido-de-la-guanilato-ciclasa-soluble-en-hiperamonemia-y-en-fallo-hepatico\/"},"modified":"2018-03-09T09:20:01","modified_gmt":"2018-03-09T09:20:01","slug":"alteraciones-de-la-regulacion-y-del-contenido-de-la-guanilato-ciclasa-soluble-en-hiperamonemia-y-en-fallo-hepatico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-de-la-regulacion-y-del-contenido-de-la-guanilato-ciclasa-soluble-en-hiperamonemia-y-en-fallo-hepatico\/","title":{"rendered":"Alteraciones de la regulaci\u00f3n y del contenido de la guanilato ciclasa soluble en hiperamonemia y en fallo hep\u00e1tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Regina Rodrigo Nicol\u00e1s <\/strong><\/h2>\n<p>La encefalopat\u00eda hep\u00e1tica (eh) es un complejo s\u00edndrome neuropsiqui\u00e1trico que se presenta en pacientes con fallo hep\u00e1tico agudo o cr\u00f3nico y conduce a alteraciones en la personalidad, la funci\u00f3n intelectual, la coordinaci\u00f3n neuromotora y en el nivel de consciencia.  la hiperamonemia se considera el principal factor responsable de algunas de las alteraciones neurol\u00f3gicas presentes en la eh. Tanto la hiperamonemia como la eh alteran la neurotransmisi\u00f3n glutamat\u00e9rgica.  la v\u00eda glutamato-\u00f3xido n\u00edtrico-gmp c\u00edclico, una de las v\u00edas transducci\u00f3n de se\u00f1ales asociada al receptor nmda (un tipo de receptor ionotr\u00f3pico de glutamato) est\u00e1 alterada en cerebelo de ratas con hiperamonemia cr\u00f3nica in vivo. La hiperamonemia altera esta v\u00eda de transducci\u00f3n de se\u00f1ales glutamato-\u00f3xido n\u00edtrico-gmp c\u00edclico a nivel de la activaci\u00f3n de la guanilato ciclasa soluble (cgs) por \u00f3xido n\u00edtrico (no) en cerebelo.  esta tesis se ha centrado en el estudio de las posibles alteraciones en el contenido y en la modulaci\u00f3n de la gcs por no en situaciones de hiperamonemia y fallo hep\u00e1tico cr\u00f3nicos en pacientes y en modelos animales de hiperamonemia cr\u00f3nica sin o con fallo hep\u00e1tico.  la cgs es un terod\u00edmero formado por dos subunidades (alfa y beta) con un grupo hemo en la subunidad beta. Cada subunidad presenta dos isoformas (alfa1, alfa2, beta1, beta2). La uni\u00f3n del \u00f3xido n\u00edtrico al grupo hemo activa la enzima hasta 200 veces.  hemos comprobado que la activaci\u00f3n de la gcs por no est\u00e1 alterada in vitro tanto en cerebelo como en corteza frontal de pacientes cirr\u00f3ticos fallecidos en como hep\u00e1tico. La activaci\u00f3n de la gcs por no est\u00e1 disminuida en cerebelo y aumentada en corteza frontal de pacientes cirr\u00f3ticos respecto a sujetos sanos.  analizando el contenido de las isoformas de gcs observamos que el contenido de las isoformas alfa de gcs est\u00e1 aumentando en cerebelo y corteza frontal en estos pacientes. Por tanto, los cambios encon<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones de la regulaci\u00f3n y del contenido de la guanilato ciclasa soluble en hiperamonemia y en fallo hep\u00e1tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones de la regulaci\u00f3n y del contenido de la guanilato ciclasa soluble en hiperamonemia y en fallo hep\u00e1tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Regina Rodrigo Nicol\u00e1s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Felipo Orts<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Grisol\u00eda <\/li>\n<li> Rodrigo g\u00f3mez Jos\u00e9 Manuel (vocal)<\/li>\n<li>agustina Garc\u00eda s\u00e1nchez (vocal)<\/li>\n<li>magdalena Torres molina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Regina Rodrigo Nicol\u00e1s La encefalopat\u00eda hep\u00e1tica (eh) es un complejo s\u00edndrome neuropsiqui\u00e1trico que se presenta en pacientes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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