{"id":27653,"date":"2018-03-09T09:20:01","date_gmt":"2018-03-09T09:20:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinantes-estructurales-del-plegamiento-y-la-interaccion-entre-fragmentos-transmembrana\/"},"modified":"2018-03-09T09:20:01","modified_gmt":"2018-03-09T09:20:01","slug":"determinantes-estructurales-del-plegamiento-y-la-interaccion-entre-fragmentos-transmembrana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinantes-estructurales-del-plegamiento-y-la-interaccion-entre-fragmentos-transmembrana\/","title":{"rendered":"Determinantes estructurales del plegamiento y la interacci\u00f3n entre fragmentos transmembrana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Mar Orz\u00e1ez Calatayud <\/strong><\/h2>\n<p>El an\u00e1lisis de secuencias gen\u00f3micas completas de diversos organismos muestra que, aproxim\u00e1damente, un 20-30% de las pautas de lectura abierta codifica para prote\u00ednas que atraviesan la membrana (arkin, brunger et al. 1997) (wallin and von heijne 1998).  Sin embargo el medio en que estas prote\u00ednas adoptan su estructura nativa y desarrollan su funci\u00f3n, la membrana, ha dificultado la aplicaci\u00f3n directa de las t\u00e9cnicas de estudio habituales para prote\u00ednas solubles.  esta dificultad se refleja en el hecho de que en la era de la explosci\u00f3n de obtenci\u00f3n de estructuras prote\u00edcas de alta resoluci\u00f3n, se limita a unas docenas el n\u00famero de prote\u00ednas de membrana resueltas.  en este trabajo se ha utilizado la oligomerizaci\u00f3n del segmento transmembrana &#8482; de una prote\u00edna modelo, glicoforina a(gpa), para tratar de aportar nuevos datos que faciliten la comprensi\u00f3n de los factores que contribuyen al proceso de plegamiento de prote\u00ednas en el interior de la membrana.  los objetivos de este trabajo han consistido en:  1,- averiguar el papel que desempe\u00f1a el extremo c-terminal del segmento tm de gpa en el proceso de dimerizaci\u00f3n de esta prote\u00edna.  2,- estudiar la contribuci\u00f3n individual de los res\u00edduos del motivo de dimerizaci\u00f3n de gpa al proceso de empaquetamiento h\u00e9lice-h\u00e9lice, utilizando un esqueleto homog\u00e9neo de polileucinas. Comprobar la contribuci\u00f3n que la longitud del fragmento hidrof\u00f3bico desempe\u00f1a en la oligomerizaci\u00f3n de este tipo de segmentos.  3,- estudiar los efectos que provoca sobre el empaquetamiento entre h\u00e9lices tm la presencia de res\u00edduos de prolina utilizando la dimerizaci\u00f3n de la prote\u00edna gpa como sistema modelo.  en conjunto, estos estudios aportan nuevos datos sobre un conjunto de factores que intervienen en el proceso de empaquetamiento entre fragmentos transmembrana, y que por lo tanto, afectan al plegamiento de prote\u00ednas transmembrana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinantes estructurales del plegamiento y la interacci\u00f3n entre fragmentos transmembrana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinantes estructurales del plegamiento y la interacci\u00f3n entre fragmentos transmembrana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Mar Orz\u00e1ez Calatayud <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ismael Mingarro Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: concepci\u00f3n Abad mazario <\/li>\n<li> Nieva escand\u00f3n Jos\u00e9 l. (vocal)<\/li>\n<li>Jos\u00e9 Manuel Gonzalez ros (vocal)<\/li>\n<li>vicente Rubio zamora (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Mar Orz\u00e1ez Calatayud El an\u00e1lisis de secuencias gen\u00f3micas completas de diversos organismos muestra que, aproxim\u00e1damente, un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[40423,12078,24267,79254,79255,11806],"class_list":["post-27653","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-concepcion-abad-mazario","tag-ismael-mingarro-munoz","tag-jose-manuel-gonzalez-ros","tag-m-mar-orzaez-calatayud","tag-nieva-escandon-jose-l","tag-vicente-rubio-zamora"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27653"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27653\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}