{"id":27658,"date":"2018-03-09T09:20:01","date_gmt":"2018-03-09T09:20:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-trafico-intracelular-en-la-senalizacion-de-la-va%c2%ada-de-hedgehog\/"},"modified":"2018-03-09T09:20:01","modified_gmt":"2018-03-09T09:20:01","slug":"papel-del-trafico-intracelular-en-la-senalizacion-de-la-va%c2%ada-de-hedgehog","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-trafico-intracelular-en-la-senalizacion-de-la-va%c2%ada-de-hedgehog\/","title":{"rendered":"Papel del tr\u00e1fico intracelular en la se\u00f1alizaci\u00f3n de la v\u00edade hedgehog"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Torroja Fungairi\u00f1o <\/strong><\/h2>\n<p>El gradiente morfogen\u00e9tico de hedgehog (hh) interviene en muchos procesos de formaci\u00f3n de patr\u00f3n durante el desarrollo de \u00f3rganos tanto en drosophila como en vertebrados. Patched (ptc), el receptor de hh, controla la difusi\u00f3n y la se\u00f1alizaci\u00f3n de hh. En esta tesis se describen dos mutantes de ptc, ptcs2 y ptc14, que tienen defectos en se\u00f1alizaci\u00f3n y secuestro respectivamente. ptcs2 tiene una mutaci\u00f3n puntual en el dominio sensible a esteroles (ssd) que induce la activaci\u00f3n de los genes diana de manera independiente de ligando. Este mutante muestra una actividad dominante negativa impidiendo la represi\u00f3n de smoothened (smo), un efector positivo de la se\u00f1alizaic\u00f3n de hh. A pesar de su fenotipo dominante negativo en se\u00f1alizaci\u00f3n, ptcs2 puede internalizar y secuestrar hh. Por un ensayo de complementaci\u00f3n hemos encontrado un mutante de ptc,ptc14, que no bloquea la difusi\u00f3n de hh ya que tiene afectada la endocitosis. Sin embargo, este mutante es capaz de controlar la expresi\u00f3n de los genes diana como la prote\u00edna silvestre. Nuestros estudios muestran que ptc limita la difusi\u00f3n de hh internaliz\u00e1ndolo a trav\u00e9s de ves\u00edculas cubiertas de clatrina por un mecanismo dependiente de dinamina.  esta internalizaci\u00f3n no se requiere par la correcta transucci\u00f3n de la se\u00f1al. adem\u00e1s, en este mutante, ptc14, y en aquellos que no producen prote\u00edna, hh todav\u00eda se localiza en endosomas en las c\u00e9lulas receptoras, lo que sugiere la existencia de un segundo mecanismo de endocitosis de hh independiente de ptc. Sin embargo, este segundo mecanismo no conduce a la degradaci\u00f3n de hh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del tr\u00e1fico intracelular en la se\u00f1alizaci\u00f3n de la v\u00edade hedgehog<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del tr\u00e1fico intracelular en la se\u00f1alizaci\u00f3n de la v\u00edade hedgehog <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Torroja Fungairi\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Guerrero Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda-bellido y Garc\u00eda de diego Antonio <\/li>\n<li>inmaculada Canal beltran (vocal)<\/li>\n<li>Jes\u00fas Avila de grado (vocal)<\/li>\n<li>elisa Marti gorostiza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Torroja Fungairi\u00f1o El gradiente morfogen\u00e9tico de hedgehog (hh) interviene en muchos procesos de formaci\u00f3n de patr\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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