{"id":27662,"date":"2018-03-09T09:20:02","date_gmt":"2018-03-09T09:20:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/role-of-diacylglycerol-receptors-during-activation-and-proliferation-in-t-lymphocytes\/"},"modified":"2018-03-09T09:20:02","modified_gmt":"2018-03-09T09:20:02","slug":"role-of-diacylglycerol-receptors-during-activation-and-proliferation-in-t-lymphocytes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/role-of-diacylglycerol-receptors-during-activation-and-proliferation-in-t-lymphocytes\/","title":{"rendered":"Role of diacylglycerol receptors during activation and proliferation in t lymphocytes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ernesto D\u00edaz Flores <\/strong><\/h2>\n<p>La homeostasis inmunol\u00f3gica es un proceso que debe estar finamente regulado. los linfocitos t de la sangre son los responsables de defender al organismo frente a agresiones externas asi como de tumores, pero tambi\u00e9n pueden llegar a alterar su funci\u00f3n y derivar en procesos tumorales dando leucemias, linfomas y otros estados patol\u00f3gicos. Por ello es importante conocer qu\u00e9 se\u00f1ales median los procesos de activaci\u00f3n y proliferacion linfocitarios a modo de poder controlarlos de manera espec\u00edfica en caso de alteraciones.  el segundo mesajero lip\u00eddico diacilglicerol as\u00ed como sus principales receptores moleculares, las prote\u00ednas quinasas c han demostrado ser muy importantes en todos los procesos celulares, siendo claves para transmitir la se\u00f1al desde los receptores en superficie hasta el n\u00facleo generando las distintas respuestas celulares.  la funci\u00f3n, distribuci\u00f3n y mecanismos  de activaci\u00f3n es espec\u00edfica para cada isoforma de pkc y viene determinado por sus dominios reguladores, que en el caso de las nuevas, que aqu\u00ed nos ocupan, es el que une diacilglicerol.  en el caso de la activaci\u00f3n linfocitica, la isoforma 0 de las pkcs se ha visto implicada en mediar las se\u00f1ales generadas tras uni\u00f3n del receptor especifico de celulas t al ant\u00edgeno. Nuestros resultados demuestran que el mecanismo de activaci\u00f3n de esta isoforma es diferente al descrito para las demas pcks implicando la fosoforilaci\u00f3n en un residuo de tirosina mediado por la tirosina quinasa lck y la uni\u00f3n del diacilglicerol generado por la fosfolipasa  c-gamma (plc-gamma). La confluencia de ambas se\u00f1ales permite que la prote\u00edna se asocie a la sinapsis que se forma en el punto de contacto del linfocito con la celula presentadora de antigeno, que es donde se inicia la respuesta temprana del linfocito.  adem\u00e1s de en activaci\u00f3n, tambi\u00e9n se puede observar la activaci\u00f3n de isoformas de  pkcs en el proceso de proliferaci\u00f3n linfocitaria. Nuestros resultados demuest<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Role of diacylglycerol receptors during activation and proliferation in t lymphocytes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Role of diacylglycerol receptors during activation and proliferation in t lymphocytes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ernesto D\u00edaz Flores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> M\u00e9rida De San Rom\u00e1n Isabel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: balbino jose Alarcon sanchez <\/li>\n<li>jens Stein (vocal)<\/li>\n<li>xose ramon Garcia bustelo (vocal)<\/li>\n<li>Mar\u00eda  senena Corbalan garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ernesto D\u00edaz Flores La homeostasis inmunol\u00f3gica es un proceso que debe estar finamente regulado. los linfocitos t [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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