{"id":27702,"date":"2018-03-09T09:20:05","date_gmt":"2018-03-09T09:20:05","guid":{"rendered":""},"modified":"2018-03-09T09:20:05","modified_gmt":"2018-03-09T09:20:05","slug":"antiagregantes-plaquetarios-referibles-a-la-estructura-de-piridazina-reacciones-catalizadas-por-paladio-en-5-halogeno-32h-piridazinonas-sa%c2%adntesis-de-3-piridazinonas-25-disustituidas-potente","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/antiagregantes-plaquetarios-referibles-a-la-estructura-de-piridazina-reacciones-catalizadas-por-paladio-en-5-halogeno-32h-piridazinonas-sa%c2%adntesis-de-3-piridazinonas-25-disustituidas-potente\/","title":{"rendered":"Antiagregantes plaquetarios referibles a la estructura de piridazina. reacciones catalizadas por paladio en 5-hal\u00f3geno-3(2h)-piridazinonas: s\u00edntesis de 3-piridazinonas-2,5-disustituidas, potentes inhibidores de la agregaci\u00f3n plaquetaria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Jos\u00e9 Coelho Cot\u00f3n <\/strong><\/h2>\n<p>Si bien las reacciones catalizadas por paladio han sido empleadas extensivamente para estudiar la reactividad de diversos sistemas y como herramienta en la preparaci\u00f3n de compuestos de inter\u00e9s faramcol\u00f3gico, curiosamente, no existen muchas referencias que describan la utilizaci\u00f3n sistem\u00e1tica de estos procedimientos en la farmacomodulaci\u00f3n y\/o diversificaci\u00f3n estructural deprototipos activos. As\u00ed, durante el desarrollo de esta memoria, nos hemos planteado como objetivo prioritario, el estudio de las posibilidades que ofrecen las reacciones catalizadas por paladio para realizar la farmacomodulaci\u00f3n de la posici\u00f3n 5 de los sistemas 6-fenil-3(2h)-piridazinona y 3(2h)-piridazinona. empleando las reacciones de suzuki, sonogashira, stille y heck se han obtenido una amplia serie de piridazinonas que contienen diferentes funciones carbonadas en la posici\u00f3n 5 del heterociclo.  el estudio de la actividad antiagregante plaquetaria de estos derivados ha permitido identificar diferentes compuestos, los cuales son potentes inhibidores de la agregaci\u00f3n plaquetaria. Adicionalmente, estos trabajos han aportado valiosa informaci\u00f3n acerca de la relaci\u00f3n estructura-actividad de estas series.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Antiagregantes plaquetarios referibles a la estructura de piridazina. reacciones catalizadas por paladio en 5-hal\u00f3geno-3(2h)-piridazinonas: s\u00edntesis de 3-piridazinonas-2,5-disustituidas, potentes inhibidores de la agregaci\u00f3n plaquetaria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Antiagregantes plaquetarios referibles a la estructura de piridazina. reacciones catalizadas por paladio en 5-hal\u00f3geno-3(2h)-piridazinonas: s\u00edntesis de 3-piridazinonas-2,5-disustituidas, potentes inhibidores de la agregaci\u00f3n plaquetaria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Jos\u00e9 Coelho Cot\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Ravi\u00f1a Rubira<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Espinosa \u00fabeda <\/li>\n<li>pilar Goya laza (vocal)<\/li>\n<li>angel Gutierrez ravelo (vocal)<\/li>\n<li>ram\u00f3n Estevez cabanas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Jos\u00e9 Coelho Cot\u00f3n Si bien las reacciones catalizadas por paladio han sido empleadas extensivamente para estudiar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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