{"id":2771,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/aspectos-clinico-biologicos-de-las-anomalias-del-transporte-de-sodio-en-la-hipertension-arterial-esencial\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"aspectos-clinico-biologicos-de-las-anomalias-del-transporte-de-sodio-en-la-hipertension-arterial-esencial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aspectos-clinico-biologicos-de-las-anomalias-del-transporte-de-sodio-en-la-hipertension-arterial-esencial\/","title":{"rendered":"Aspectos clinico-biologicos de las anomalias del transporte de sodio en la hipertension arterial esencial."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Garces Lopez <\/strong><\/h2>\n<p>Partiendo de la hipotesis de la heterogeneidad del sindrome hipertensivo, las alteraciones de los mecanismos del transporte de sodio transmembranario en la hipertension y el aumento de la agregabilidad a determinados antigenos hla en estudios epidemiologicos de hipertensos, el objetivo del presente estudio es el de efectuar una valoracion comparativa de las alteraciones clinico-metabolicas (fenotipo), encontradas en la poblacion hipertensa, dividida en subpoblaciones segun las anomalias cineticas encontradas (fenotipo intermedio), asi como su relacion con los antigenos del sistema hla y grupos sanguineos-rh (genotipo), teniendo como referencia el estudio con el estudio normotensa. Se realiza estudio de los mecanismos del transporte sodico con posterior estudio cinetico (km y vmax) en eritrocitos de la poblacion control (35 p.) E hipertensa (37 p.), valoracion clinica, analitica, ecocardiografica y estudio del sistema hla y grupos sanguineos-rh.  se concluye que, exiten diferentes anomalias cineticas, signficativamente diferenciadas, que definen a las subpoblaciones de hipertensos (disminucion de la afinidad para el sodio interno, en pacientes bomba (-) y cotransporte (-), aumento de la vmax para la contratransporte (+), aumento de la velocidad constante para los flujos pasivos en los permiabilidad pasiva (+) y ausencia de anomalia definida en el indeterminado.  la repercusion clinico-metabolica no es uniforme, los pacientes contransporte (+) y bomba (-) estan mas afectados a nivel miocardico y lipico. Los contratransporte (+) presentan mayor sobrepeso, glucemia, uricemia y hemoconcentracion. Existe una fuerte agregacion familiar hipertensiva en la mayoria de las subpoblaciones. El antigeno hla b 21 es significativamente prevalente en los bomba (-). Los pacientes con mas de una anomalia cinetica, presentan mayor repercusion organica con tiempo de evolucion mas prolongado. En los grupos sanguineos se detectan aumentos del riesgo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aspectos clinico-biologicos de las anomalias del transporte de sodio en la hipertension arterial esencial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aspectos clinico-biologicos de las anomalias del transporte de sodio en la hipertension arterial esencial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Garces Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Diez Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Jos\u00e9 Morales Olivas <\/li>\n<li>Gines Sanz Romero (vocal)<\/li>\n<li>Juan  F Ascaso Gimilio (vocal)<\/li>\n<li>Jes\u00fas Olivares Mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Garces Lopez Partiendo de la hipotesis de la heterogeneidad del sindrome hipertensivo, las alteraciones de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,11771,139,179],"tags":[8313,11774,11773,11776,11775,11772],"class_list":["post-2771","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-genetica-clinica","category-medicina-interna","category-nefrologia","tag-francisco-jose-morales-olivas","tag-gines-sanz-romero","tag-javier-diez-Martinez","tag-jesus-olivares-martin","tag-juan-f-ascaso-gimilio","tag-luis-garces-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=2771"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2771\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=2771"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=2771"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=2771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}