{"id":27713,"date":"2018-03-09T09:20:06","date_gmt":"2018-03-09T09:20:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-por-hormona-tiroidea-y-otros-factores-de-transcripcion-de-la-expresion-del-gen-galphail-de-rata-caracterizacion-del-promotor\/"},"modified":"2018-03-09T09:20:06","modified_gmt":"2018-03-09T09:20:06","slug":"regulacion-por-hormona-tiroidea-y-otros-factores-de-transcripcion-de-la-expresion-del-gen-galphail-de-rata-caracterizacion-del-promotor","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-por-hormona-tiroidea-y-otros-factores-de-transcripcion-de-la-expresion-del-gen-galphail-de-rata-caracterizacion-del-promotor\/","title":{"rendered":"Regulaci\u00f3n por hormona tiroidea y otros factores de transcripci\u00f3n de la expresi\u00f3n del gen galphail de rata. caracterizaci\u00f3n del promotor"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  \u00e1lvarez Garc\u00eda M. Mar <\/strong><\/h2>\n<p>La hormona tiroidea ejerce importantes efectos sobre la mayor\u00eda de los tejidos de los vertebrados, tanto sobre su crecimiento y desarrollo, como sobre su actividad metab\u00f3lica. Uno de los principales \u00f3rganos diana de la t3 es el cerebro, donde la ausencia de esta hormona durante el desarrollo provoca da\u00f1os irreversibles, ya que procesos como sinaptog\u00e9nesis, mielinizaci\u00f3n y migraci\u00f3n son procesos dependientes de t3. Las prote\u00ednas g heterotrim\u00e9ricas, son capaces de interaccionar con un gran n\u00famero de receptores de neuromoduladores, neurotransmisores y hormonas, y transmitir la informaci\u00f3n al interior celular, gracias a que regulan la actividad de diversos efectores espec\u00edficos. Se sabe que la hormona tiroidea lleva a cabo su acci\u00f3n, al menos parcialmente, modulando alg\u00fan componente de la ruta de las prote\u00ednas g.  nosotros hemos observado que en ratas durante el desarrollo, el hipotiroidismo regula la expresi\u00f3n del gen galpahail en cerebelo, mesenc\u00e9falo y coraz\u00f3n. en cerebelo, la ausencia de t3 reduce los niveles de arnm y de prote\u00edna galphail. Los tipos celulares afectados son las neuronas granulares y en mayor extensi\u00f3n las c\u00e9lulas de purkinje. Estos efectos observados en cerebelo, son probablemente consecuencia de una regulaci\u00f3n indirecta de la hormona tiroidea sobre el promotor del gen galphail, en la que podr\u00eda estar implicada la prote\u00edna c\/ebpbeta. En mesenc\u00e9falo, el hipotiroidismo aumenta los niveles de arnm galphail, pero no tiene ning\u00fan efecto a nivel proteico, resultados que sugieren una compleja acci\u00f3n de t3. En coraz\u00f3n el hipotiroidismo aumenta los niveles de arnm y de prote\u00edna de galphail. Estos efectos observados en coraz\u00f3n, los podemos explicar por una represi\u00f3n directa de la hormona tiroidea sobre el promotor del gen galphail, habiendo dos secuencias responsables de este efecto, una localizda en la zona -145 a -134, y otra en las 25 primeras bases del ex\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n por hormona tiroidea y otros factores de transcripci\u00f3n de la expresi\u00f3n del gen galphail de rata. caracterizaci\u00f3n del promotor<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n por hormona tiroidea y otros factores de transcripci\u00f3n de la expresi\u00f3n del gen galphail de rata. caracterizaci\u00f3n del promotor <\/li>\n<li><strong>Autor:<\/strong>\u00a0  \u00e1lvarez Garc\u00eda M. Mar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gregorio Angel Santos Montes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Bl\u00e1zquez fern\u00e1ndez <\/li>\n<li>M\u00aa josefa Toro nozal (vocal)<\/li>\n<li>angel Pascual Garc\u00eda (vocal)<\/li>\n<li>Juan  Carlos Rodriguez-manzaneque escribano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00e1lvarez Garc\u00eda M. Mar La hormona tiroidea ejerce importantes efectos sobre la mayor\u00eda de los tejidos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[79399,37515,3180,76090,63567,14322],"class_list":["post-27713","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-alvarez-garcia-m-mar","tag-angel-pascual-garcia","tag-enrique-blazquez-fernandez","tag-gregorio-angel-santos-montes","tag-juan-carlos-rodriguez-manzaneque-escribano","tag-ma-josefa-toro-nozal"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27713"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27713\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}