{"id":27714,"date":"2018-03-09T09:20:06","date_gmt":"2018-03-09T09:20:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-interaccion-de-la-protea%c2%adna-del-surfactante-a-sp-a-con-diferentes-ligandos-en-la-superficie-alveolar\/"},"modified":"2018-03-09T09:20:06","modified_gmt":"2018-03-09T09:20:06","slug":"bases-moleculares-de-la-interaccion-de-la-protea%c2%adna-del-surfactante-a-sp-a-con-diferentes-ligandos-en-la-superficie-alveolar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-interaccion-de-la-protea%c2%adna-del-surfactante-a-sp-a-con-diferentes-ligandos-en-la-superficie-alveolar\/","title":{"rendered":"Bases moleculares de la interacci\u00f3n de la prote\u00edna del surfactante a (sp-a) con diferentes ligandos en la superficie alveolar"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda-verdugo De Lucas Ignacio <\/strong><\/h2>\n<p>La prote\u00edna sp-a del surfactante pulmonar forma parte del sistema inmune innato del pulm\u00f3n, implicado en la defensa inmediata frente a una amplia variedad de pat\u00f3genos y toxinas. La sp-a pertenece a una familia de prote\u00ednas estructuralmente homologa denominada colectina, lectinas tipo-c (dependientes de calcio) con un dominio de col\u00e1geno. La capacidad de la sp-a de unirse a distintos ligandos (calcio, azucares, fosfol\u00edpidos y prote\u00ednas) justifica su multiplicidad funcional:  a,- mejorar la actividad biof\u00edsica del surfactante.  b,- aglutinar pat\u00f3genos y toxinas, disminuyendo su toxicidad y promoviendo su eliminaci\u00f3n por fagocitosis.  c,- modular la respuesta inflamatoria en el alveolo. Esta actividad multifuncional de la sp-a contribuye a evitar el colapso de los alv\u00e9olos durante la espiraci\u00f3n, a mantener el espacio alveolar esterilizado, y a limitar la respuesta inflamatoria frente a endotoxinas inhaladas.  la multiplicidad funcional de la sp-a depende de su compleja estructura oligom\u00e9rica, formada por 18 cadenas polipept\u00eddicas, que en humanos y primates, pero no en otros mam\u00edferos, proceden de dos genes funcionales distintos (sp-a1 y sp-a2). La proporci\u00f3n en la que se encuentran las cadenas polipept\u00eddicas sp-a1 y sp-a2 en la prote\u00edna humana y la importancia funcional de contener dos cadenas polip\u00e9ptidicas, que diferen principalmente en el dominio de col\u00e1geno no se conoce. En esta memoria se describe, por primera vez, las diferencias estructurales y funcionales entre las prote\u00ednas recombinantes humanas sp-a1 y sp-a2 (procedentes de un solo gen) expresadas en c\u00e9lulas de insecto y entre la forma co-expresada procedente de ambos genes. Por otra parte, se ha caracterizado la interacci\u00f3n de la sp-a humana, nativa y recombinantes, con el lipopolisacarido  bacteriano (lps) presente en soluci\u00f3n, as\u00ed como incorporado en monocapas de dipalmitilfosfatidilcolina en la interfase aire-l\u00edquido. Adem\u00e1s se ha demostrado que l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases moleculares de la interacci\u00f3n de la prote\u00edna del surfactante a (sp-a) con diferentes ligandos en la superficie alveolar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases moleculares de la interacci\u00f3n de la prote\u00edna del surfactante a (sp-a) con diferentes ligandos en la superficie alveolar <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda-verdugo De Lucas Ignacio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cristina Casals Carro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: antonia Lizarbe m. <\/li>\n<li>Mar\u00eda Gasset vega (vocal)<\/li>\n<li>Luis Rivas l\u00f3pez (vocal)<\/li>\n<li>Rafael Garc\u00eda ca\u00f1ero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda-verdugo De Lucas Ignacio La prote\u00edna sp-a del surfactante pulmonar forma parte del sistema inmune innato del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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