{"id":27727,"date":"2018-03-09T09:20:07","date_gmt":"2018-03-09T09:20:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/novel-flow-cytometry-based-assays-for-the-evaluation-of-primary-immune-disease\/"},"modified":"2018-03-09T09:20:07","modified_gmt":"2018-03-09T09:20:07","slug":"novel-flow-cytometry-based-assays-for-the-evaluation-of-primary-immune-disease","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/novel-flow-cytometry-based-assays-for-the-evaluation-of-primary-immune-disease\/","title":{"rendered":"Novel flow cytometry based assays for the evaluation of primary immune disease"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arthur Kanhonou Rodolphe <\/strong><\/h2>\n<p>Las inmunodeficiencias primarias son un grupo heterog\u00e9neo de des\u00f3rdenes caracterizados por defectos en genes implicados en la respuesta inmune. las inmunodeficiencias cong\u00e9nitas deben diagnosticarse tan pronto sea posible, bien en neonatos o durante el per\u00edodo de gestaci\u00f3n. El desarrollo de ensayos cl\u00ednicos sencillos, r\u00e1pidos y objetivos que puedan realizarse en cantidades m\u00ednimas de muestra, conducen al pronto diagn\u00f3stico.  muchas de las inmunodeficiencias primarias se caracterizan por defectos celulares que son cuantificables por citometr\u00eda de flujo. El objetivo de este proyecto de tesis ha sido el de relatar nuestra experiencia en el desarrollo de t\u00e9cnicas que permitan el diagn\u00f3stico precoz de aquellos individuos afectados por tres inmunodeficiencias cong\u00e9nitas en concreto. Las inmunodeficiencias objeto de estudio tienen en com\u00fan que, a pesar de su diversa etiolog\u00eda, resultan en anormalidades en el n\u00famero y\/o funciones de los neutr\u00f3filos son:  * deficiencia de adhesi\u00f3n leucocitaria tipo i. El procedimiento desarrollado se basa en la demostraci\u00f3n de que las inegrinas beta2 et\u00e1n parcial o totalmente ausentes en la superficie de leucocitos estimulados in vitro obtenidos a partir de pacientes afectados por esta inmunodeficiencia.  * enfermedad granulomatosa cr\u00f3nica. El ensayo pone de manifiesto la incapacidad de los polimorfonucleares de los pacientes afectados para generar compuestos oxidantes y por tanto destruir a los microorganismos fagocitados.  * s\u00edndrome de hiper-igm. Mediante este ensayo se demuestra la ausencia del ligando cd40 en linfocitos. T-cooperadores, de forma que los linfocitos b de los individuos afectados, al no ser incluidos a diferenciarse, no experimentan cambios de isotipo y son incapaces de producir iga. Igc e ige.  por \u00faltimo, se describe el caso cl\u00ednico de una paciente diagnosticada con el s\u00edndrome de hipereosinofilia, que sin ser una inmunodeficiencia, ha sido evaluado mediante diver<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Novel flow cytometry based assays for the evaluation of primary immune disease<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Novel flow cytometry based assays for the evaluation of primary immune disease <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arthur Kanhonou Rodolphe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Roc Ros Palau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Segura garcia del rio <\/li>\n<li>lynne Yenush (vocal)<\/li>\n<li>Juan Carbonell gisbert (vocal)<\/li>\n<li>Jos\u00e9 Javier Forment millet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arthur Kanhonou Rodolphe Las inmunodeficiencias primarias son un grupo heterog\u00e9neo de des\u00f3rdenes caracterizados por defectos en genes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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