{"id":27729,"date":"2018-03-09T09:20:08","date_gmt":"2018-03-09T09:20:08","guid":{"rendered":""},"modified":"2018-03-09T09:20:08","modified_gmt":"2018-03-09T09:20:08","slug":"evaluacion-del-tratamiento-con-interferon-alfa-2a-2b-y-ribavirina-en-pacientes-con-hepatitis-c-cronica-previamente-no-respondedores-a-inteferon-en-monoterapia-metanalisis-y-evaluacion-economica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/evaluacion-del-tratamiento-con-interferon-alfa-2a-2b-y-ribavirina-en-pacientes-con-hepatitis-c-cronica-previamente-no-respondedores-a-inteferon-en-monoterapia-metanalisis-y-evaluacion-economica\/","title":{"rendered":"Evaluaci\u00f3n del tratamiento con interferon alfa 2a\/2b y ribavirina en pacientes con hepatitis c cr\u00f3nica previamente no respondedores a inteferon en monoterapia: metan\u00e1lisis y evaluaci\u00f3n econ\u00f3mica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ram\u00f3n San Miguel Elcano <\/strong><\/h2>\n<p>La hepatitis c es una enfermedad que supone la primera causa de transplante hep\u00e1tico en nuestro entorno. El tratamiento en los pacientes previamente no respondedores a interferon tiene una eficacia inferior a la de otras poblaciones, y los ensayos cl\u00ednicos relativos a esta poblaci\u00f3n no siempre presentan resultados coincidentes.  se lleva a cabo un metan\u00e1lisis en el que se analizan diferentes opicones terap\u00e9uticas con el fin de determinar la eficacia del tratamiento.  la opci\u00f3n terap\u00e9utica m\u00e1s eficaz result\u00f3 la terapia combinada con interferon y ribavirina durante 12 meses. Se analizaron adem\u00e1s terapia combinada a diferentes dosis y duraci\u00f3n, interferon en monoterapia y no tratamiento.  con los datos de eficacia y mediante la utilizaci\u00f3n de modelos de markov, simulamos la evoluci\u00f3n de una cohorte de pacientes con el fin de estimar los costes futuros derivados de la progresi\u00f3n de la enfermedad, as\u00ed como los beneficios resultantes de la respuesta virol\u00f3gica sostenida obtenida con el tratamiento farmacol\u00f3gico.  la estrategia m\u00e1s eficaz, terapia combinada durante 12 meses, alcanza una respuesta virol\u00f3gica sostenida en el 20,5% de los pacientes (ic95% 15,5%-26%). esta opci\u00f3n supone una ganancia de 1,55 a\u00f1os de vida ajustados por calidad (avac) al ser comparado frente a la opci\u00f3n no tratamiento lo que supone una raz\u00f3n coste-efectividad de 6.073 euros \/ avac.  el ratio desde- efectividad incremental est\u00e1 por debajo de los l\u00edmites considerados coste-efectivos para nuestro sistema sanitario.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n del tratamiento con interferon alfa 2a\/2b y ribavirina en pacientes con hepatitis c cr\u00f3nica previamente no respondedores a inteferon en monoterapia: metan\u00e1lisis y evaluaci\u00f3n econ\u00f3mica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n del tratamiento con interferon alfa 2a\/2b y ribavirina en pacientes con hepatitis c cr\u00f3nica previamente no respondedores a inteferon en monoterapia: metan\u00e1lisis y evaluaci\u00f3n econ\u00f3mica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ram\u00f3n San Miguel Elcano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Guillen Grima<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Esteban  mur <\/li>\n<li>Fernando Anto\u00f1anzas villar (vocal)<\/li>\n<li>Fernando Rodr\u00edguez artalejo (vocal)<\/li>\n<li>alfonso Carvajal Garc\u00eda-pando (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ram\u00f3n San Miguel Elcano La hepatitis c es una enfermedad que supone la primera causa de transplante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[12802,5988,12656,8237,13799,79431],"class_list":["post-27729","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-alfonso-carvajal-garcia-pando","tag-fernando-antonanzas-villar","tag-fernando-rodriguez-artalejo","tag-francisco-guillen-grima","tag-rafael-esteban-mur","tag-ramon-san-miguel-elcano"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27729"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27729\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}