{"id":27743,"date":"2018-03-09T09:20:09","date_gmt":"2018-03-09T09:20:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-a-nivel-genetico-y-ultraestructural-de-la-deficiencia-en-el-transportador-de-carnitina-acil-carnitina-empleado-como-modelo-aspergillus-nidulans\/"},"modified":"2018-03-09T09:20:09","modified_gmt":"2018-03-09T09:20:09","slug":"estudio-a-nivel-genetico-y-ultraestructural-de-la-deficiencia-en-el-transportador-de-carnitina-acil-carnitina-empleado-como-modelo-aspergillus-nidulans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/estudio-a-nivel-genetico-y-ultraestructural-de-la-deficiencia-en-el-transportador-de-carnitina-acil-carnitina-empleado-como-modelo-aspergillus-nidulans\/","title":{"rendered":"Estudio a nivel genetico y ultraestructural de la deficiencia en el transportador de carnitina\/acil carnitina empleado como modelo aspergillus nidulans."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Oscar Martinez Jimenez <\/strong><\/h2>\n<p>La deficiencia de la translocasa de carnitina\/acil-carnitina es la enfermedad gen\u00e9tico-metab\u00f3lica m\u00e1s grave que afecta a la b-oxidaci\u00f3n de \u00e1cidos grasos. esta metabolopat\u00eda es letal en humanos y tambi\u00e9n en el resto de animales vertebrados e invertebrados, lo que imposibilita el desarrollo de modelos animales para su estudio. Sin embargo, en aspergillus nidulans, esta deficiencia no es letal de manera que cepas deficientes en el gen acuh, que codifica la tcac de este hongo, pueden ser cultivadas en fuentes de carbono y energ\u00eda alternativas a los \u00e1cidos grasos como, por ejemplo, az\u00facares y glicerol. esta condici\u00f3n nos ha permitido estudiar distintos aspectos de relevancia gen\u00e9tico-molecular de esta metabolopat\u00eda.  en primer lugar, se han caracterizado las mutaciones presentes en las 6 cepas acuh- de a. Nidulans existentes en nuestro laboratorio. Adem\u00e1s, se ha demostrado la localizaci\u00f3n celular exclusiva de este transportador en la membrana interna mitocondrial de a. Nidulans, descart\u00e1ndose la posible localizaci\u00f3n dual, peroxisomal y mitocondrial, propuesta para esta prote\u00edna por algunos autores. Finalmente, se han aislado supresores extrag\u00e9nicos de la deficiencia en la tcac de a. Nidulans, habi\u00e9ndose clonado y caracterizado un gen supresor de esta deficiencia, el gen sola. La mutaci\u00f3n sola7 en este gen, que codifica para el factor de terminaci\u00f3n de la s\u00edntesis de prote\u00ednas erf1 de a. Nidulans, suprime la deficiencia de alelos sin sentido en el gen de la tcac.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio a nivel genetico y ultraestructural de la deficiencia en el transportador de carnitina\/acil carnitina empleado como modelo aspergillus nidulans.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio a nivel genetico y ultraestructural de la deficiencia en el transportador de carnitina\/acil carnitina empleado como modelo aspergillus nidulans. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Oscar Martinez Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ram\u00f3n De Lucas Iglesias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Laborda rodriguez <\/li>\n<li>Antonio Ribes rubio (vocal)<\/li>\n<li> Pe\u00f1alva soto Miguel angel (vocal)<\/li>\n<li>nicolas Jouve de la barreda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oscar Martinez Jimenez La deficiencia de la translocasa de carnitina\/acil-carnitina es la enfermedad gen\u00e9tico-metab\u00f3lica m\u00e1s grave que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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