{"id":27746,"date":"2018-03-09T09:20:09","date_gmt":"2018-03-09T09:20:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/procesos-de-regulacion-y-transmodulacion-de-los-receptores-a1-de-adenosina-y-metabotropicos-de-glutamato-en-cerebro-de-rata-durante-la-gestion\/"},"modified":"2018-03-09T09:20:09","modified_gmt":"2018-03-09T09:20:09","slug":"procesos-de-regulacion-y-transmodulacion-de-los-receptores-a1-de-adenosina-y-metabotropicos-de-glutamato-en-cerebro-de-rata-durante-la-gestion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/castilla-la-mancha\/procesos-de-regulacion-y-transmodulacion-de-los-receptores-a1-de-adenosina-y-metabotropicos-de-glutamato-en-cerebro-de-rata-durante-la-gestion\/","title":{"rendered":"Procesos de regulaci\u00f3n y transmodulaci\u00f3n de los receptores a1 de adenosina y metabotr\u00f3picos de glutamato en cerebro de rata durante la gesti\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Agust\u00edn Le\u00f3n Navarro <\/strong><\/h2>\n<p>1,- la gestaci\u00f3n modulada los receptores a1 de adenosina en cerebro de rata gestante, produciendo su down-regulaci\u00f3n asociada a un incremento en la funcionalidad del sistema, justificado por un aumento de la afinidad del receptor por su ligando y por los niveles de prote\u00edna alfagi3. Dicha modulaci\u00f3n parece ser producida por el incremento de la liberaci\u00f3n de adenosina end\u00f3gena producido durante la gestaci\u00f3n.  2,- la gestaci\u00f3n up-regula los receptores metabotr\u00f3picos de glutamato en cerebro de rata sin provocar variaciones  significativas en la funcionalidad del sistema. Tal modulaci\u00f3n puede ser causada por la disminuci\u00f3n de la liberaci\u00f3n de glutamato end\u00f3geno producido por los receptores a1 de adenosina estimulados por la adenosina liberada durante la gestaci\u00f3n.  3,- la administraci\u00f3n de cafe\u00edna o teofilina a ratas durante todo el per\u00edodo gestacional produce una down-regulaci\u00f3n de los receptores a1 de adenosina y las prote\u00ednas alfagi1,2 tanto en cerebro materno como fetal. Dicha down-regulaci\u00f3n va asociada a una p\u00e9rdida significativa de la respuesta del sistema en madres, sin afectar a dicha funcionalidad de los fetos. La p\u00e9rdida de receptores en las ratas consumidoras de cafe\u00edna podr\u00eda ser la responsable del aumento de actividad locomotora de dichos animales durante la gestaci\u00f3n.  4,- la administraci\u00f3n de cafe\u00edna o teofilina durante la gestaci\u00f3n produce un down-regulaci\u00f3n de los receptores metabotr\u00f3picos de glutamato y su sistema efector la fosfolipasa c, tanto en cerebro materno como fetal. La p\u00e9rdida de receptores afecta fundamentalmente al tipo mglu1 en las madres y puede afectar a otros tipos en los fetos, y en general, est\u00e1 asociada a una disminuci\u00f3n de la respuesta de los receptores, tnato en madres como en fetos.  5,- la administraci\u00f3n cr\u00f3nica de r-pia durante la gestaci\u00f3n produce una down-regulaci\u00f3n de los receptores a1 de adenosina y metabotr\u00f3picos de glutamato, tanto en cerebro materno como<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Procesos de regulaci\u00f3n y transmodulaci\u00f3n de los receptores a1 de adenosina y metabotr\u00f3picos de glutamato en cerebro de rata durante la gesti\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Procesos de regulaci\u00f3n y transmodulaci\u00f3n de los receptores a1 de adenosina y metabotr\u00f3picos de glutamato en cerebro de rata durante la gesti\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Agust\u00edn Le\u00f3n Navarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Castilla-la mancha<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mairena Martin Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: galo Ramirez ortiz <\/li>\n<li>Jes\u00fas Pintor just (vocal)<\/li>\n<li>Rafael Franco fernandez (vocal)<\/li>\n<li>Rafael Luj\u00e1n miras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Agust\u00edn Le\u00f3n Navarro 1,- la gestaci\u00f3n modulada los receptores a1 de adenosina en cerebro de rata [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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