{"id":27769,"date":"2018-03-09T09:20:11","date_gmt":"2018-03-09T09:20:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-una-vacuna-recombinante-y-transmisible-frente-a-la-mixomatosis-y-la-enfermedad-hemorragica-del-conejo-para-su-aplicacion-en-conejo-silvestre\/"},"modified":"2018-03-09T09:20:11","modified_gmt":"2018-03-09T09:20:11","slug":"desarrollo-de-una-vacuna-recombinante-y-transmisible-frente-a-la-mixomatosis-y-la-enfermedad-hemorragica-del-conejo-para-su-aplicacion-en-conejo-silvestre","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-una-vacuna-recombinante-y-transmisible-frente-a-la-mixomatosis-y-la-enfermedad-hemorragica-del-conejo-para-su-aplicacion-en-conejo-silvestre\/","title":{"rendered":"Desarrollo de una vacuna recombinante y transmisible frente a la mixomatosis y la enfermedad hemorr\u00e1gica del conejo para su aplicaci\u00f3n en conejo silvestre"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ram\u00edrez De Paz Miguel \u00e1ngel <\/strong><\/h2>\n<p>Existen diversas vacunas frente a la mixomatosis basadas en cepas de virus mixoma atenuadas en cultivos celulares. Tambi\u00e9n existen vacunas frente a la enfermedad hemorr\u00e1gica del conejo basadas en virus inactivado. Dichas vacunas han demostrado su eficacia en el control de ambas enfermedades en explotaciones de conejos dom\u00e9sticos, pero no resultan adecuadas para proteger las posibilidades de conejos silvestres.  la vacunaci\u00f3n de animales silvestres resulta una tarea dif\u00edcil puesto que en muchos casos no son viables los m\u00e9todos  convencionales de administraci\u00f3n inidividual de la vacuna. Una alternativa posible es el empleo de vectores virales capaces de transmitirse a trav\u00e9s de una poblaci\u00f3n animal. Este abordaje resulta especialmente indicado para la administraci\u00f3n de inmun\u00f3genos en aquellas poblaciones de animales silvestres cuya distribuci\u00f3n, tama\u00f1o y tasa de renovaci\u00f3n de la poblaci\u00f3n considerada imposibilita el uso de las t\u00e9cnicas de captura o el empleo de cebos como m\u00e9todos para administrar vacunas. El conejo europeo (oryctolagus cuniculus) es un ejemplo de \u00e9ste tipo de poblaci\u00f3n.  teniendo en cuenta \u00e9stas premisas, hemos estudiado la posibilidad de vacunaci\u00f3n de conejos silvestres frente a mixomatosis y enfermedad hemorr\u00e1gica del conejo mediante el empleo de un recombinante mv-vp60 capaz de difundirse por la poblaci\u00f3n de conejos mediante transmisi\u00f3n horizontal. El virus recombinante mixoma-rhdv se basa en una cepa de campo del virus mixoma, denominada cepa 6918, que fue seleccionada por sus especiales caracter\u00edsticas de resultar no virulenta en conejos y ser al mismo tiempo capaz de transmitirse de un conejo a otro. Para construir el virus recombinante se insert\u00f3 el gen de la prote\u00edna vp60 del virus rhdv en el genoma de la cepa 6918 del virus mixoma. La vp60 es la prote\u00edna estructural mayoritaria del virus rhdv y ha demostrado ser altamente inmun\u00f3gena y capaz de conferir protecci\u00f3n total frente a dosis<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de una vacuna recombinante y transmisible frente a la mixomatosis y la enfermedad hemorr\u00e1gica del conejo para su aplicaci\u00f3n en conejo silvestre<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de una vacuna recombinante y transmisible frente a la mixomatosis y la enfermedad hemorr\u00e1gica del conejo para su aplicaci\u00f3n en conejo silvestre <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ram\u00edrez De Paz Miguel \u00e1ngel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Torres Trillo Juan  M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esperanza Gomez-lucia duato <\/li>\n<li>Francisco Sobrino castello (vocal)<\/li>\n<li>Francisco Parra fernandez (vocal)<\/li>\n<li>esther Blanco lavilla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ram\u00edrez De Paz Miguel \u00e1ngel Existen diversas vacunas frente a la mixomatosis basadas en cepas de virus [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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