{"id":27772,"date":"2018-03-09T09:20:11","date_gmt":"2018-03-09T09:20:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-y-deplecion-tisular-de-la-flumequina-y-su-princial-metabolito-7-oh-flumequina-en-pollos-de-engorde\/"},"modified":"2018-03-09T09:20:11","modified_gmt":"2018-03-09T09:20:11","slug":"farmacocinetica-y-deplecion-tisular-de-la-flumequina-y-su-princial-metabolito-7-oh-flumequina-en-pollos-de-engorde","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-y-deplecion-tisular-de-la-flumequina-y-su-princial-metabolito-7-oh-flumequina-en-pollos-de-engorde\/","title":{"rendered":"Farmacocin\u00e9tica y depleci\u00f3n tisular de la flumequina y su princial metabolito 7-oh-flumequina en pollos de engorde"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cruz Moreno Carlos Omar De La <\/strong><\/h2>\n<p>La flumequina, fluoroquinolona de primera generaci\u00f3n, es un antibi\u00f3tico benzoquinolizina, presenta buena actividad frente a bacterias gram-negativas y moderada actividad frente a bacterias gram-positivas, pseudomona aeruginosa y microorganismos anaerobios. Act\u00faa a nivel de las enzimas bacterianas adn girasa y topoisomerasa iv. Se tuiliza ampliamente en medicina veterinaria para el tratamiento de infecciones por microorganismos pat\u00f3genos tales como escherichia coli, y salmonella spp. En aves, no existen datos que describan el perfil cin\u00e9tico de la flumequina.  el objetivo del trabajo fue determinar el comportamiento cin\u00e9tico de la flumequina en la especie animal de consumo humano de pollos de engorde tras dosis \u00fanica de 12 mg\/kg intravenosa y oral, as\u00ed como estudiar la distribuci\u00f3n y depleci\u00f3n tisular de sus residuos al objeto de determinar el par\u00e1metro de tiempo de retirada que asegure el cumplimiento del limite m\u00e1ximo de residuos (kmr) legislado para esta quinolona en aves, como medida de seguridad alimentaria. Cuarenta y seis pollos de engorde, machos ross, de 3 kg p.V.Fueron distribuidos en 3 grupos para realizar.  1,- estudio farmacocin\u00e9tico de flumequina tras dosis \u00fanica intravenosa de 12 mg\/kg p.V. (8 pollos).  2,- estudio farmacocin\u00e9tico de flumequina tras dosis \u00fanica oral de 12 mg\/kg p.V. (8 pollos).  3,- estudio de depleci\u00f3n tisular de flumequina y metabolitos tras administraci\u00f3n oral de 25 mg\/kg\/d\u00eda durante cinco d\u00edas consecutivos (30 pollos).  tras tratamiento, a diferentes periodos de tiempo, se tomaron muestras sangu\u00edneas y tisulares (ri\u00f1\u00f3n, h\u00edgado, m\u00fasculo y piel+grasa) en cada animal, y se determin\u00f3 la concentraci\u00f3n de flumequina y de sus metabolitos principales en estas muestras recogidas siguiendo la metodolog\u00eda anal\u00edtica de cromatograf\u00eda l\u00edquida con detecci\u00f3n de fluorescencia descrita previamente por yorke y froc (2000).  en nuestros resultados observamos que la flumequina principalm<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica y depleci\u00f3n tisular de la flumequina y su princial metabolito 7-oh-flumequina en pollos de engorde<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica y depleci\u00f3n tisular de la flumequina y su princial metabolito 7-oh-flumequina en pollos de engorde <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cruz Moreno Carlos Omar De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mart\u00ednez Larra\u00f1aga M. Rosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arturo ramon Anadon navarro <\/li>\n<li>david Ordo\u00f1ez escudero (vocal)<\/li>\n<li>arturo Hardisson de la torre (vocal)<\/li>\n<li>Rafael Bala\u00f1a fouce (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cruz Moreno Carlos Omar De La La flumequina, fluoroquinolona de primera generaci\u00f3n, es un antibi\u00f3tico benzoquinolizina, presenta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[10092,7412,79528,4565,7588,9412],"class_list":["post-27772","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-arturo-hardisson-de-la-torre","tag-arturo-ramon-anadon-navarro","tag-cruz-moreno-carlos-omar-de-la","tag-david-ordonez-escudero","tag-Martinez-larranaga-m-rosa","tag-rafael-balana-fouce"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27772"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27772\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}