{"id":27811,"date":"2018-03-09T09:20:14","date_gmt":"2018-03-09T09:20:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-apoptosis-miocardica-en-la-insuficiencia-carda%c2%adaca-asociada-con-la-cardiopata%c2%ada-hipertensiva\/"},"modified":"2018-03-09T09:20:14","modified_gmt":"2018-03-09T09:20:14","slug":"estudio-de-la-apoptosis-miocardica-en-la-insuficiencia-carda%c2%adaca-asociada-con-la-cardiopata%c2%ada-hipertensiva","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/estudio-de-la-apoptosis-miocardica-en-la-insuficiencia-carda%c2%adaca-asociada-con-la-cardiopata%c2%ada-hipertensiva\/","title":{"rendered":"Estudio de la apoptosis mioc\u00e1rdica en la insuficiencia card\u00edaca asociada con la cardiopat\u00edahipertensiva"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ar\u00e1nzazu Gonzalez Miqueo <\/strong><\/h2>\n<p>Se ha descrito la presencia de apoptosis de los cardiomiocitos en una gran variedad de modelos experimentales de hipertensi\u00f3n arterial (hta) y en diversas cardiopat\u00edas humanas, incluyendo la cardipat\u00eda hpertensiva sin insuficiencia card\u00edaca (ic). Por lo tanto, nos planteamos la hip\u00f3tesis de que la estimulaci\u00f3n de la apoptosis de los cardiomiocitos y la inhibici\u00f3n de la v\u00eda de supervivencia de la gp130 en los mismos pueden desempe\u00f1ar un papel en la transici\u00f3n de la hipertrof\u00eda ventricular izquierda (hvi) compensadora a la ic en la evoluci\u00f3n de la hta. Para verificar esta hip\u00f3tesis hemos analizado biopsias endomioc\u00e1rdicas de 28  pacientes hipertensos con hvi y funci\u00f3n card\u00edaca normal (grupo sin ic) y 24 pacientes hipertensos con hvi y manifestaciones cl\u00ednicas de ic (grupo con ic). La detecci\u00f3n y cuantificaci\u00f3n de la apotosis se realiz\u00f3 mediante la t\u00e9cnica del tunel, y los resultados se confirmaron con un an\u00e1lisis inmunohistoqu\u00edmico de la forma activa de la caspasa-3. Las densidades celulares se cuantificaron en secciones te\u00f1idas con tricr\u00f3mico de masson. La expresi\u00f3n micoc\u00e1rdica del receptor gp130 se analiz\u00f3 mediante western blot. La apoptosis global se encontraba aumentada en los pacientes del grupo con ic con respecto a los del grupo sin ic tanto en cuanto al \u00edndice apopt\u00f3tico (p menor 0,01) como al inmunomarcaje para la caspasa-3 (p menor 0,05). La apoptosis de los cardiomiocitos (p menor 0,01) y la de los no cardiomiocitos (p menor 0.05) se encontraban aumentadas en el grupo con ic comparado con el grupo sin ic. Tanto la densidad de los cardiomiocitos como la de los no cardiomiocitos se enocntraba disminuida (p menor 0,01) en los pacientes del grupo con ic con respecto a los del grupo sin ic. Se encontr\u00f3 una correlaci\u00f3n inversa entre la apoptosis de los cardiomiocitos y la densidad de estas c\u00e9lulas (r=0.628, p menor 0,001) en todos los pacientes.  en cuanto a los posibles mecanismos implicados en este aum<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la apoptosis mioc\u00e1rdica en la insuficiencia card\u00edaca asociada con la cardiopat\u00edahipertensiva<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la apoptosis mioc\u00e1rdica en la insuficiencia card\u00edaca asociada con la cardiopat\u00edahipertensiva <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ar\u00e1nzazu Gonzalez Miqueo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fortu\u00f1o Cebamanos M. Antonia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li>eduardo Deteresa galvan (vocal)<\/li>\n<li> Berrazueta fern\u00e1ndez Jos\u00e9 ram\u00f3n de (vocal)<\/li>\n<li>\u00e1ngel Llamas lombard\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ar\u00e1nzazu Gonzalez Miqueo Se ha descrito la presencia de apoptosis de los cardiomiocitos en una gran variedad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[39016,79619,67991,7921,17998,79620],"class_list":["post-27811","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-angel-llamas-lombardia","tag-aranzazu-gonzalez-miqueo","tag-berrazueta-fernandez-jose-ramon-de","tag-eduardo-deteresa-galvan","tag-edurne-cenarruzabeitia-sagarminaga","tag-fortuno-cebamanos-m-antonia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27811"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27811\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}