{"id":27866,"date":"2018-03-09T09:20:19","date_gmt":"2018-03-09T09:20:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-polimorfismo-de-la-apolipoprotea%c2%adna-e-sobre-el-esquema-lipa%c2%addico-en-diabetes-mellitus-tipo-2\/"},"modified":"2018-03-09T09:20:19","modified_gmt":"2018-03-09T09:20:19","slug":"efectos-del-polimorfismo-de-la-apolipoprotea%c2%adna-e-sobre-el-esquema-lipa%c2%addico-en-diabetes-mellitus-tipo-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/efectos-del-polimorfismo-de-la-apolipoprotea%c2%adna-e-sobre-el-esquema-lipa%c2%addico-en-diabetes-mellitus-tipo-2\/","title":{"rendered":"Efectos del polimorfismo de la apolipoprote\u00edna e sobre el esquema lip\u00eddico en diabetes mellitus tipo 2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esperanza Aguillo Guti\u00e9rrez <\/strong><\/h2>\n<p>La apolipoprote\u00edna e es codificada por un gen polim\u00f3rfico dando lugar a tres alelos comunes: e2, e3 y e4.  la apoe  interviene en el metabolismo lip\u00eddico y circula unidad a quilomicrones, quilomicrones remanentes, vldl, idl y hdl.  objetivo  el objetivo de la tesis es evaluar los genotipos apoe, la frecuencia al\u00e9lica, los efectos del polimorfismo apoe en los niveles plasm\u00e1ticos de lipoprote\u00ednas incluyendo el tama\u00f1o de la part\u00edcula ldl y su composici\u00f3n y sobre la actividad de lipoprote\u00edn-lipasa en una muestra de pacientes con diabetes mellitus tipo 2.  material y m\u00e9todos  se analiza una muestra de 126 pacientes con diabetes mellitus tipo 2. La determinaci\u00f3n de genotipo apoe se realiza por pcr tras aislar dna, se dirige con hhai y visualizaci\u00f3n tras electroforesis en el gel de poliacrilamida.  conclusiones  1,- en nuestra muestra de pacientes con diabetes mellitus tipo 2, es el 71,43% ten\u00edan genotipo e3\/e3, el 15,88% genotipo e3\/e4 y el 12,69% genotipo e3\/e2. No se encontraron individuos homocigotos para e2 (e2\/e2) ni e4 (e4\/e4), ni heterocigots e4\/e2.  2,- el colesterol ldl fue significativamente menor en portadores del alelo e2 que en protadores del alelo e3 y e4.  3,- el colesterol total, la apolipoprote\u00edna b y el colesterol no-hdl fue menor, en el l\u00edmite de la significaci\u00f3n estad\u00edstica, en portadores del alelo e2 que en el resto de genotipos.  4,- los triglic\u00e9ridos, hdl-c, apoa1, lp(a), \u00e1cidos grasos libres y la homociste\u00eda no mostraron diferencias entre los genotipos apoe.  5,- la microalbuminuria fue significativamente superior en los sujetos con genotipo e3\/e2 que en el resto de genotipos.  6,- la actividad de lipoprote\u00edn lipasa y hep\u00e1tico lipasa no mostr\u00f3 diferencias entre los genotipos apoe.  7,- la concentraci\u00f3n de subfracciones ldl (ldl1, ldl2, ldl3, ldl4, ldl5, ldl6), el cociente (ldl1+ldl2+ld13\/ldl4+ldl5+ldl6) y la concentraci\u00f3n de sus componentes lip\u00eddicos y proteicos fue similar ent<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del polimorfismo de la apolipoprote\u00edna e sobre el esquema lip\u00eddico en diabetes mellitus tipo 2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del polimorfismo de la apolipoprote\u00edna e sobre el esquema lip\u00eddico en diabetes mellitus tipo 2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esperanza Aguillo Guti\u00e9rrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Faure Nogueras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gabriel Guill\u00e9n mart\u00ednez <\/li>\n<li>armando Giner soria (vocal)<\/li>\n<li>Francisco Javier Salvador rodr\u00edguez (vocal)<\/li>\n<li>Antonio P\u00e9rez p\u00e9rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esperanza Aguillo Guti\u00e9rrez La apolipoprote\u00edna e es codificada por un gen polim\u00f3rfico dando lugar a tres alelos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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