{"id":27875,"date":"2018-03-09T09:20:20","date_gmt":"2018-03-09T09:20:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-las-vitaminas-antioxidantes-a-c-y-e-y-de-los-glucocorticoides-sobre-la-hipoplasia-pulmonar-y-cardiaca-en-el-modelo-de-hernia-diafragmatica-experimental\/"},"modified":"2018-03-09T09:20:20","modified_gmt":"2018-03-09T09:20:20","slug":"efectos-de-las-vitaminas-antioxidantes-a-c-y-e-y-de-los-glucocorticoides-sobre-la-hipoplasia-pulmonar-y-cardiaca-en-el-modelo-de-hernia-diafragmatica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-las-vitaminas-antioxidantes-a-c-y-e-y-de-los-glucocorticoides-sobre-la-hipoplasia-pulmonar-y-cardiaca-en-el-modelo-de-hernia-diafragmatica-experimental\/","title":{"rendered":"Efectos de las vitaminas antioxidantes a, c y e y de los glucocorticoides sobre la hipoplasia pulmonar y cardiaca en el modelo de hernia diafragm\u00e1tica experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonz\u00e1lez Reyes M. Salom\u00e9 <\/strong><\/h2>\n<p>La hernia diafragm\u00e1tica cong\u00e9nita (hdc) es una malformaci\u00f3n relativamente frecuente (1:2200 recien nacidos vivos) que consiste en la presencia de un orificio diagragm\u00e1tico, generalmente posterolateral izquierdo, a trav\u00e9s del cual pasan las v\u00edsceras abdominales al t\u00f3rax comprimiendo el pulm\u00f3n del mismo lado, el contralateral y el coraz\u00f3n.  junto a este conflicto de espacio, la funci\u00f3n pulmonar neonatal se ve comprometida por una hipoplasia anat\u00f3mica que incluye una ramificaci\u00f3n broncoalveolar insuficiente con reducci\u00f3n de espacio alveolar, por anomal\u00edas arteriolares que generan una vasoconstricci\u00f3n extrema y por una inmadurez pulmonar con disminuci\u00f3n del contendio de fosfol\u00edpidos tensoactivos, especialmente fosfatidil-colina disaturada. A causa de estos y otros defectos, especialmente neurol\u00f3gicos, cardiacos y del aparato locomotor, as\u00ed como determinadas trisom\u00edas, se produce una hipertensi\u00f3n pulmonar persistente en el periodo neonatal inmediato y la mortalidad consiguiente llega a ser muy elevada a pesar de los medios m\u00e1s modernos de tratamiento, inclu\u00eddo el uso de ventilatorios oscilatorios de alta frecuencia, vasodilatadores pulmonares espec\u00edficos como el \u00f3xido n\u00edtrico y de la oxigenaci\u00f3n con membrana extracorp\u00f3rea.  en este trabajo se ha evidenciado los efectos beneficiosos de los antioxidantes y los glucocorticoides en la hernia diafragm\u00e1tica cong\u00e9nita, utilizando el modelo de la malformaci\u00f3n inducida en fetos de rata por la administraci\u00f3n del terat\u00f3geno nitrofen. Dichos tratamientos inducen mejor\u00edas a nivel celular, tisular y molecular en neumocitos humanos y en animales con hernia diafragm\u00e1tica producida experimentalmente sugiriendo que, aunque el origen de la enfermedad humano no sea el mismo, si los mecanismos son comunes, podr\u00eda estar justificado antenatalmente tratamientos de este tipo en el contexto cl\u00ednico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de las vitaminas antioxidantes a, c y e y de los glucocorticoides sobre la hipoplasia pulmonar y cardiaca en el modelo de hernia diafragm\u00e1tica experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de las vitaminas antioxidantes a, c y e y de los glucocorticoides sobre la hipoplasia pulmonar y cardiaca en el modelo de hernia diafragm\u00e1tica experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonz\u00e1lez Reyes M. Salom\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Antonio Tovar Larrucea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Quero jim\u00e9nez <\/li>\n<li>pilar Santesteban ruiz (vocal)<\/li>\n<li>adolf Valls soler (vocal)<\/li>\n<li>Luis Morales foches (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonz\u00e1lez Reyes M. Salom\u00e9 La hernia diafragm\u00e1tica cong\u00e9nita (hdc) es una malformaci\u00f3n relativamente frecuente (1:2200 recien nacidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[9607,79758,7519,58994,79760,79759],"class_list":["post-27875","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-adolf-valls-soler","tag-gonzalez-reyes-m-salome","tag-jose-quero-jimenez","tag-juan-antonio-tovar-larrucea","tag-luis-morales-foches","tag-pilar-santesteban-ruiz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27875"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27875\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}