{"id":27885,"date":"2018-03-09T09:20:21","date_gmt":"2018-03-09T09:20:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelizacion-farmacocinetica-farmacodinamica-de-la-actividad-hematologica-de-agentes-antitumorales\/"},"modified":"2018-03-09T09:20:21","modified_gmt":"2018-03-09T09:20:21","slug":"modelizacion-farmacocinetica-farmacodinamica-de-la-actividad-hematologica-de-agentes-antitumorales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/modelizacion-farmacocinetica-farmacodinamica-de-la-actividad-hematologica-de-agentes-antitumorales\/","title":{"rendered":"Modelizaci\u00f3n farmacocin\u00e9tica\/farmacodin\u00e1mica de la actividad hematol\u00f3gica de agentes antitumorales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Segura Sanz <\/strong><\/h2>\n<p>Actualmente la mielosupresi\u00f3n representa uno de los mayores efectos t\u00f3xicos que producen los quimioterapicos. Por esta raz\u00f3n una buena parte de la investigaci\u00f3n en este campo esta dedicada a establecer la relaci\u00f3n entre la exposici\u00f3n del organismo a estos agentes y el efecto hematol\u00f3gico que producen. El fin \u00faltimo es mejorar la dosificaci\u00f3n de los f\u00e1rmacos antineopl\u00e1sicos y por tanto, la terap\u00e9utica del c\u00e1ncer.  las relaciones farmacocin\u00e9ticas\/farmacodin\u00e1micas han mostrado con anterioridad ser una herramienta muy \u00fatil para describir la evoluci\u00f3n temporal de distintas respuestas farmacol\u00f3gicas.  el presente trabajo recoge tres estudios donde distintos modelos pk\/pd semifisiol\u00f3gicos fueron aplicados satisfactoriamente para describir el curso de la hematotoxicidad de distintos agente antitumorales, tanto a nivel pr-cl\u00ednico, como en el desarrollo cl\u00ednico de un nuevo f\u00e1rmaco. Estos modelos semifisiol\u00f3gicos han mostrado ser m\u00e1s adecuados que los emp\u00edricos por varias razones:  1,- son capaces de describir tanto el grado como la duraci\u00f3n de la mielosupresi\u00f3n.  2,- pueden ser aplicados tras varios ciclos de tratamiento e incluso tras diferentes reg\u00edmenes de dosificaci\u00f3n.  3,- y son capaces de discriminar entre los par\u00e1metros relacionados con el f\u00e1rmaco y los par\u00e1metros relacionados con el sistema, de modo que pueden aplicarse satisfactoriamente a distintos f\u00e1rmacos y bajo distintas circunstancias.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelizaci\u00f3n farmacocin\u00e9tica\/farmacodin\u00e1mica de la actividad hematol\u00f3gica de agentes antitumorales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelizaci\u00f3n farmacocin\u00e9tica\/farmacodin\u00e1mica de la actividad hematol\u00f3gica de agentes antitumorales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Segura Sanz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ignacio Fernandez De Troconiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li>dolors Soy muner (vocal)<\/li>\n<li>concepci\u00f3n Peraire guitart (vocal)<\/li>\n<li>amparo S\u00e1nchez navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Segura Sanz Actualmente la mielosupresi\u00f3n representa uno de los mayores efectos t\u00f3xicos que producen los quimioterapicos. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[9483,14228,79783,79784,17998,51407],"class_list":["post-27885","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-amparo-sanchez-navarro","tag-concepcion-peraire-guitart","tag-cristina-segura-sanz","tag-dolors-soy-muner","tag-edurne-cenarruzabeitia-sagarminaga","tag-jose-ignacio-fernandez-de-troconiz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27885"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27885\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}