{"id":27936,"date":"2018-03-09T09:20:25","date_gmt":"2018-03-09T09:20:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-papel-de-la-p38alfa-mapk-en-la-apoptosis-utilizando-celulas-deficientes-en-p38alfa\/"},"modified":"2018-03-09T09:20:25","modified_gmt":"2018-03-09T09:20:25","slug":"caracterizacion-del-papel-de-la-p38alfa-mapk-en-la-apoptosis-utilizando-celulas-deficientes-en-p38alfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-papel-de-la-p38alfa-mapk-en-la-apoptosis-utilizando-celulas-deficientes-en-p38alfa\/","title":{"rendered":"Caracterizaci\u00f3n del papel de la p38alfa mapk en la apoptosis utilizando c\u00e9lulas deficientes en p38alfa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Zuluaga Rodr\u00edguez <\/strong><\/h2>\n<p>La p38alfa mapk es una serina\/treonina quinasa de la superfamilia de las mapks. Las p38 mapks cl\u00e1sicamente se han relacionado con procesos de respuesta a estr\u00e9s. Sin embargo, datos m\u00e1s recientes indican que se pueden activar en respuesta a otras muchas se\u00f1ales regulando diversas funciones celulares incluida la apoptosis y supervivencia celular. Dado que existen cuatro isoformas de p38 mapks, distintas isoformas podr\u00edan jugar funciones diferentes. Nuestro trabajo se ha centrado en el estudio del papel que juega la isoforma alfa en el balance apoptosis\/supervivencia, utilizando para ello c\u00e9lulas deficientes en dicha quinasa. Los resultados presentados en esta memoria demuestran que las p38alfa sensibiliza a los cardiomioctos y fibroblastos embrionarios de rat\u00f3n frente a la apoptosis activadas por diversos est\u00edmulos a trav\u00e9s de diferentes mecanismos.     por una parte, la p38alfa induce un aumento en los niveles de prote\u00ednas pro-apopt\u00f3ticas como bax y fas, probablemente a trav\u00e9s de la disminuci\u00f3n de la forma activa del factor de transcripci\u00f3n stat3 (fosfo-ser727-stat3). Por otro lado, la p38alfa mapk regula negativamente la ruta de supervivencia de las erk  mapks y de la pi3k\/akt.  en concreto, la p38alfa mapk mediar\u00eda la desfosforilaci\u00f3n e inactivaci\u00f3n de la akt a trav\u00e9s de la activaci\u00f3n de la serina\/treonina fosfatasa pp21a. Esta estimulaci\u00f3n del a actividad de la pp2a ocurre en regiones caveolares de membrana, donde la subunidad catal\u00edtica de la pp2a (pp2ac) permanece unida a caveolina-1 y rac-1 formando un complejo. La formaci\u00f3n de este complejo es dependiente de adhesi\u00f3n celular, por lo que podr\u00eda depender de la activaci\u00f3n de integrinas y\/o cadherinas. A su vez, la interacci\u00f3n entre la caveolina-1, la pp2ac y rac-1 depende de la activaci\u00f3n de tirosina quinasas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del papel de la p38alfa mapk en la apoptosis utilizando c\u00e9lulas deficientes en p38alfa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del papel de la p38alfa mapk en la apoptosis utilizando c\u00e9lulas deficientes en p38alfa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Zuluaga Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Almudena Porras Gallo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Guzm\u00e1n pastor <\/li>\n<li>carmen Guerrero arroyo (vocal)<\/li>\n<li> Rodr\u00edguez nebreda Manuel \u00e1ngel (vocal)<\/li>\n<li>daniel Sanchis morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Zuluaga Rodr\u00edguez La p38alfa mapk es una serina\/treonina quinasa de la superfamilia de las mapks. Las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[24622,79901,79902,39707,43783,79900],"class_list":["post-27936","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-almudena-porras-gallo","tag-carmen-guerrero-arroyo","tag-daniel-sanchis-morales","tag-manuel-guzman-pastor","tag-rodriguez-nebreda-manuel-angel","tag-susana-zuluaga-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=27936"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/27936\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=27936"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=27936"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=27936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}