{"id":27970,"date":"2018-03-09T09:20:28","date_gmt":"2018-03-09T09:20:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-las-metaloprotea%c2%adnasas-de-matriz-en-la-patogenesis-de-la-lesion-de-la-mucosa-intestinal-en-modelos-experimentales-de-enfermedad-inflamatoria-intestinal\/"},"modified":"2018-03-09T09:20:28","modified_gmt":"2018-03-09T09:20:28","slug":"implicacion-de-las-metaloprotea%c2%adnasas-de-matriz-en-la-patogenesis-de-la-lesion-de-la-mucosa-intestinal-en-modelos-experimentales-de-enfermedad-inflamatoria-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-las-metaloprotea%c2%adnasas-de-matriz-en-la-patogenesis-de-la-lesion-de-la-mucosa-intestinal-en-modelos-experimentales-de-enfermedad-inflamatoria-intestinal\/","title":{"rendered":"Implicaci\u00f3n de las metaloprote\u00ednasas de matriz en la patog\u00e9nesis de la lesi\u00f3n de la mucosa intestinal en modelos experimentales de enfermedad inflamatoria intestinal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Medina Martin <\/strong><\/h2>\n<p>Introducci\u00f3n  las metaloproteinasas de matriz (mmps) son enzimas capaces de degradar los diferentes componentes de la matriz extracelular y producir la lesi\u00f3n tisular. Dichas enzimas pueden jugar un papel importante en la lesi\u00f3n tisular en la enfermedad inflamatoria intestinal humana.  hip\u00f3tesis  1,- las mmps pueden jugar un papel importante en la lesi\u00f3n tisular asociada a la inflamaci\u00f3n intestinal experimental.  2,- el empleo de inhibidores de las mmps puede limitar el da\u00f1o tisular en diferentes modelos experimentales de colitis.  objetivos  primer estudio: valorar el efecto de la fenantrolina sobre el curso cl\u00ednico, caracter\u00edsticas mascrosc\u00f3picas e histol\u00f3gicas, as\u00ed como liberaci\u00f3n de mediadores de la inflamaci\u00f3n en dos modelos experimentales de colitits, la colitis inducida por \u00e1cido trinitrobenzensulf\u00f3nico (tnbs) y la colitis inducida por dextrano sulfato s\u00f3dico (dss).  segundo estudio: investigar la actividad y expresi\u00f3n de las gelatinazas (mmp-9 y mmp-2) en el modelo inducido por el dss y valorar el efecto de un inhibidor espec\u00edfico de las mmps (cgs 27023 a) sobre el curso cl\u00ednico y el grado de lesi\u00f3n histol\u00f3gica en dicho modelo experimental.  metodos  primer estudio: se indujo la colitis por tnbs y dss en 4 grupos. La fenantrolina se administr\u00f3 por v\u00eda oral a dosis de 20 mg\/kg\/d\u00eda, mientras que los grupos control recibieron placebo. En el \u00faltimo d\u00eda se procedi\u00f3 a la di\u00e1lisis col\u00f3nica para la mediaci\u00f3n de eicosanoides intraluminales y las ratas fueron sacrificadas para estudio macrosc\u00f3pico e histol\u00f3gico del colon, as\u00ed como de la mieloperoxida (mp0) tisular.  segundo estudio: se indujo la colitis por dss en un grupo de 8 ratas, mientras que otro recibi\u00f3 agua solamente. La actividad y expresi\u00f3n de las mmps fue medida por zimograf\u00eda y western-blot en los d\u00edas 3 y 5 posteriores a la inducci\u00f3n de la colitis. En otro experimento, 2 grupos de ratas con colitis (20 por grupo) fueron tratad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de las metaloprote\u00ednasas de matriz en la patog\u00e9nesis de la lesi\u00f3n de la mucosa intestinal en modelos experimentales de enfermedad inflamatoria intestinal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de las metaloprote\u00ednasas de matriz en la patog\u00e9nesis de la lesi\u00f3n de la mucosa intestinal en modelos experimentales de enfermedad inflamatoria intestinal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Medina Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Guarner Aguiar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Guardia mass\u00f3 <\/li>\n<li>josep Mar\u00eda Pique badia (vocal)<\/li>\n<li>enrique Quintero carrion (vocal)<\/li>\n<li>ignacio Lizasoain hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Medina Martin Introducci\u00f3n las metaloproteinasas de matriz (mmps) son enzimas capaces de degradar los diferentes componentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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