{"id":27995,"date":"2018-03-09T09:20:30","date_gmt":"2018-03-09T09:20:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sa%c2%adntesis-y-evaluacion-biologica-preliminar-de-nuevos-antagonistas-de-los-receptores-del-neuropeptido-y-para-el-tratamiento-de-la-obesidad\/"},"modified":"2018-03-09T09:20:30","modified_gmt":"2018-03-09T09:20:30","slug":"diseno-sa%c2%adntesis-y-evaluacion-biologica-preliminar-de-nuevos-antagonistas-de-los-receptores-del-neuropeptido-y-para-el-tratamiento-de-la-obesidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/diseno-sa%c2%adntesis-y-evaluacion-biologica-preliminar-de-nuevos-antagonistas-de-los-receptores-del-neuropeptido-y-para-el-tratamiento-de-la-obesidad\/","title":{"rendered":"Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica preliminar de nuevos antagonistas de los receptores del neurop\u00e9ptido y para el tratamiento de la obesidad"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Moreno Herrera <\/strong><\/h2>\n<p>Se define la obesidad como una enfermedad cr\u00f3nica, heterog\u00e9nea y multifactorial, y es considerada como factor de riesgo para la salud. Aunque la oms ha definido la obesidad como la epidemia del siglo xxi debido al aumento progresivo de la preValencia en estos \u00faltimos a\u00f1os, la pr\u00e1ctica inexistencia de f\u00e1rmacos antiobesidad hacen del tratamiento farmacol\u00f3gico un objetivo de inter\u00e9s.  el papel de la v\u00eda npy\u00e9rgica en la estimulaci\u00f3n e inhibici\u00f3n del apetito ha sido descrito. El npy, una prote\u00edna de 36 amino\u00e1cidos (familia de los p\u00e9ptidos pancre\u00e1ticos) y localizda abundantemente a nivel del snc y perif\u00e9rico, es el orex\u00edgeno m\u00e1s potente conocidos, actuando a trav\u00e9s de los receptores y1 e y5. Surgen as\u00ed el inter\u00e9s en la s\u00edntesis de nuevos agentes antiobesidad antagonistas de los receptores y1\/y5 del npy.  se han sintetizado 54 nuevos compuestos, originales, derivados del n\u00facleo arilsulfonamidometilciclohexilo, y divididos, seg\u00fan el grupo funcional que les caracteriza, en ocho series de productos: serie i\/derivados de amida, serie ii\/derivados de amina, serie iii\/derivados de n-formilo, serie iv\/derivados de urea y tiourea, serie v\/derivados de guanidina, serie vi\/derivados de hidracinurea, serie vii\/derivados de carbohidracida y serie viii\/productos sin ciclohexilo. La s\u00edntesis qu\u00edmica se acompa\u00f1a con una descripci\u00f3n de los mecanismos correspondientes a cada serie. El mecanismo de obtenci\u00f3n de amidas basado en la edxistencia de d\u00edmeros de \u00e1cido carbox\u00edlico en reacci\u00f3n se demuestra mediante un estudio de espectroscopia ir (se ha calculado la constante de equilibrio de dimerizaci\u00f3n), y se propone un mecanismo en la obtenci\u00f3n de los derivados de la serie ii, al no ser descrito en la bibliograf\u00eda. Los compuestos que se presentan han sido identificados mediante espectroscopia de ir, rmn (mono y bidimensional), an\u00e1lisis de chn, hplc y espectrometr\u00eda de masas. Los derivados de la serie iii han sido estudiados medi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica preliminar de nuevos antagonistas de los receptores del neurop\u00e9ptido y para el tratamiento de la obesidad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica preliminar de nuevos antagonistas de los receptores del neurop\u00e9ptido y para el tratamiento de la obesidad <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Moreno Herrera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Monge Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel S\u00e1nchez gonz\u00e1lez <\/li>\n<li>argimiro Rivero rosales (vocal)<\/li>\n<li>Miguel Fernandez bra\u00f1a (vocal)<\/li>\n<li>yolanda Sainz s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Moreno Herrera Se define la obesidad como una enfermedad cr\u00f3nica, heterog\u00e9nea y multifactorial, y es considerada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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