{"id":28024,"date":"2018-03-09T09:20:33","date_gmt":"2018-03-09T09:20:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-y-regulacion-transcripcional-de-los-canales-de-calcio-en-la-celula-cromafa%c2%adn\/"},"modified":"2018-03-09T09:20:33","modified_gmt":"2018-03-09T09:20:33","slug":"expresion-y-regulacion-transcripcional-de-los-canales-de-calcio-en-la-celula-cromafa%c2%adn","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/miguel-hernandez-de-elche\/expresion-y-regulacion-transcripcional-de-los-canales-de-calcio-en-la-celula-cromafa%c2%adn\/","title":{"rendered":"Expresi\u00f3n y regulaci\u00f3n transcripcional de los canales de calcio en la c\u00e9lula cromaf\u00edn"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Benavides Puerta M. Amparo <\/strong><\/h2>\n<p>El ion calcio act\u00faa como se\u00f1al intracelular regulando multitud de funciones celulares, tales como la liberaci\u00f3n de neurotransmisores, la expresi\u00f3n g\u00e9nica o la muerte celular. Aumentos excesivos en la concentraci\u00f3n de calcio intracelular, pueden desencadenar diferentes proceso patol\u00f3gicos que conducen a la muerte celular. Por ello las c\u00e9lulas han desarrollado diversos mecanismos que les permiten regular la concentraci\u00f3n de calcio intracelular, entre los que destacan; los reservorios intracelulares que liberan o captan calcio y mol\u00e9culas tamponadoras de calcio. En las c\u00e9lulas excitables, los canales de calcio dependientes de voltaje (ccdv) constituyen la ruta principal de regulaci\u00f3n del flujo de iones calcio al interior celular.  los estudio farmacol\u00f3gicos y electrofisiol\u00f3gicos han demostrado la existencia de diferentes tipos de ccdv de alto umbral de activaci\u00f3n: l, n, p\/q y r. dichos canales son complejos multiprot\u00e9icos formados por la combinaci\u00f3n de varias subunidades. La subunidad alpha1 constituye la subunidad principal formadora del canal i\u00f3nica. Hasta la actualidad se han identificado al menos 7 genes diferentes que codificanla subunidad alpha1: cav1.1, cav1.2, cav1.3 y cav1.4 pertenecientes al ccdv tipo l, cav2.1 (canal tipo p\/q), cav2.2 (canal tipo n) y cav2.3 (canal tipo r).  entre las diversas funciones que desempe\u00f1a el flujo de calcio a trav\u00e9s de los ccdv en las c\u00e9lulas cromafines, nosotros estamos especialmente interesados en la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica, y en concreto, en la regulaci\u00f3n transcripcional de los propios ccdv.  por medio de la rt-pcr determinamos la existencia de diferentes tipos de subunidades alpha1 de los ccdv en las c\u00e9lulas cromafines bovinas: cav1.1, cav1.2, cav1.3, cav2.1, cav2.2 y cav2.3.  el estudio comparativo de las c\u00e9lulas en cultivo y la m\u00e9dula adrenal intacta demuestra que existen grandes diferencias en el patr\u00f3n de expresi\u00f3n de dichas subunidades. Por otra part<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n y regulaci\u00f3n transcripcional de los canales de calcio en la c\u00e9lula cromaf\u00edn<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n y regulaci\u00f3n transcripcional de los canales de calcio en la c\u00e9lula cromaf\u00edn <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Benavides Puerta M. Amparo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Soledad Calvo Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: roberto Gallego fernandez <\/li>\n<li>constancio Gonzalez mart\u00ednez (vocal)<\/li>\n<li>ram\u00f3n Trullas oliva (vocal)<\/li>\n<li>valent\u00edn Ce\u00f1a callejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Benavides Puerta M. Amparo El ion calcio act\u00faa como se\u00f1al intracelular regulando multitud de funciones celulares, tales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[37169],"tags":[80112,34225,14027,33124,69832,7038],"class_list":["post-28024","post","type-post","status-publish","format-standard","hentry","category-miguel-hernandez-de-elche","tag-benavides-puerta-m-amparo","tag-constancio-gonzalez-Martinez","tag-ramon-trullas-oliva","tag-roberto-gallego-fernandez","tag-soledad-calvo-Martinez","tag-valentin-cena-callejo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28024"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28024\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}