{"id":28062,"date":"2018-03-09T09:20:36","date_gmt":"2018-03-09T09:20:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-cla%c2%adnico-diagnosticas-del-peptido-ghrelin-en-la-infancia\/"},"modified":"2018-03-09T09:20:36","modified_gmt":"2018-03-09T09:20:36","slug":"implicaciones-cla%c2%adnico-diagnosticas-del-peptido-ghrelin-en-la-infancia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-cla%c2%adnico-diagnosticas-del-peptido-ghrelin-en-la-infancia\/","title":{"rendered":"Implicaciones cl\u00ednico-diagn\u00f3sticas del p\u00e9ptido ghrelin en la infancia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leandro Soriano Guill\u00e9n <\/strong><\/h2>\n<p>Ghrelin es un p\u00e9ptido secretado fundamentalmente en el aparato intestinal que estimula la secreci\u00f3n de hormona de crecimiento, acth y prolactina, adem\u00e1s de estimular el apetito e inducir adipog\u00e9nesis.  con el tiempo, se han ido descubriendo nuevas funciones de esta hormona, como son la de estar relacionado con el p\u00e1ncreas endocrino, presentar una posible implicaci\u00f3n en la funci\u00f3n gonadal as\u00ed como en la funci\u00f3n tiroidea. aparte de las acciones endocrinas, ghrelin modifica las resistencias vasculares sist\u00e9micas favoreciendo el aumento del \u00edndice card\u00edaco. Tambi\u00e9n se ha relacionado a esta hormona con la inhibici\u00f3n in vitro de ciertas neoplasias, y con la regulaci\u00f3n del sue\u00f1o.  los objetivos de nuestra tesis doctoral eran determinar los niveles plasm\u00e1ticos de ghrelin desde la etapa fetal hasta la etapa adulta y, ver si exist\u00edan diferencias debidas al sexo, as\u00ed como interacciones con datos antropom\u00e9tricos y bioqu\u00edmicos. Debido a la estrecha relaci\u00f3n de ghrelin con el metabolismo y la ingesta, decidimos estudiar las concentraciones de este p\u00e9ptido en dos situaciones de malnutrici\u00f3n, cuales son, obesidad y anorexia, tanto al diagn\u00f3stico como tras p\u00e9rdida o recuperaci\u00f3n ponderal. Por \u00faltimo, para intentar comprender la posible implicaci\u00f3n de ghrelin en el metabolismo hidrocarbonado, se determinaron los niveles de ghrelin en pacientes afectos de diabetes mellitus tipo 1 al diagn\u00f3stico y tras la administraci\u00f3n de insulina en tres momentos puntuales: 48 horas, al mes y a laos 4 meses de insulinoterapia. Asimismo, con el fin de discernir la posible interacci\u00f3n entre ghrelin y glucemia, determinamos las tasas plasm\u00e1ticas de ghrelin en ni\u00f1os obesos tras realizar una sobrecarga oral de glucosa.  de los datos obtenidos en nuestra tesis doctoral, podemos concluir:  1,- la aparici\u00f3n de ghrelin en etapas precoces de la gesti\u00f3n sugiere una funci\u00f3n tr\u00f3fica de este p\u00e9ptido, y su aumento llamativo tempranamente en la vi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones cl\u00ednico-diagn\u00f3sticas del p\u00e9ptido ghrelin en la infancia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones cl\u00ednico-diagn\u00f3sticas del p\u00e9ptido ghrelin en la infancia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leandro Soriano Guill\u00e9n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/12\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Argente Oliver<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Quero jim\u00e9nez <\/li>\n<li>ram\u00f3n Ca\u00f1ete estrada (vocal)<\/li>\n<li>Manuel Arias (vocal)<\/li>\n<li>Francisco Rivas crespo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leandro Soriano Guill\u00e9n Ghrelin es un p\u00e9ptido secretado fundamentalmente en el aparato intestinal que estimula la secreci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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