{"id":28098,"date":"2004-09-01T00:00:00","date_gmt":"2004-09-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ensayo-cla%c2%adnico-sobre-la-eficacia-de-la-amoxicilina-ac-clavulanico-frente-a-placebo-en-la-prevencion-de-infeccion-postoperatoria-tras-la-exodoncia-de-terceros-molares-inferiores-incluidos\/"},"modified":"2004-09-01T00:00:00","modified_gmt":"2004-09-01T00:00:00","slug":"ensayo-cla%c2%adnico-sobre-la-eficacia-de-la-amoxicilina-ac-clavulanico-frente-a-placebo-en-la-prevencion-de-infeccion-postoperatoria-tras-la-exodoncia-de-terceros-molares-inferiores-incluidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/ensayo-cla%c2%adnico-sobre-la-eficacia-de-la-amoxicilina-ac-clavulanico-frente-a-placebo-en-la-prevencion-de-infeccion-postoperatoria-tras-la-exodoncia-de-terceros-molares-inferiores-incluidos\/","title":{"rendered":"Ensayo cl\u00ednico sobre la eficacia de la amoxicilina\/\u00e1c. clavul\u00e1nico frente a placebo, en la prevenci\u00f3n de infecci\u00f3n postoperatoria, tras la exodoncia de terceros molares inferiores incluidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Diez Garcia M. Antonia <\/strong><\/h2>\n<p>La exodoncia del tercer molar inferior (tmi) representa entre un 40%-60% de la actividad de los servicios de cirug\u00eda maxilofacial. La infecci\u00f3n postoperatoria est\u00e1 descrita entre un 0%-45%. El tratamiento con antibi\u00f3tico sist\u00e9mico a todos los pacientes para evitar la infecci\u00f3n es una pr\u00e1ctica generalizada sobre la que no existe evidencia cient\u00edfica.  objetivo: determinar frente a placebo la eficacia\/ineficacia del tratamiento preventivo postoperatorio con amoxicilina\/clavul\u00e1nico 500\/125mg. En la exodonica de tmi incluidos, conocer la frecuencia de complicaci\u00f3n infecciosa en el grupo experimental (g1) y control (g2) y ver si existen variables que influyan en ella.Dise\u00f1o: ensayo cl\u00ednico aleatorio, autorizado por la agencia espa\u00f1ola del medicamento, controlado.  paralelo, doble ciego, hip\u00f3tesis de trabajo: h0=p2-p1 menor &#8211; 0,067 h1=p2-p1 mayor 0,067 (p1= 3,3% infecci\u00f3n con antibi\u00f3tico en nustro medio y p2=10% frecuencia estimada con placebo). Para contrastar esta hip\u00f3tesis se precisa una muestra final de n=490. Ambito: servicio de cirug\u00eda maxilofacial del hospital p\u00fablico de cruces, vizcaya. Pacientes: sujetos sanos de ambos sexos entre 18-60 a\u00f1os con firma del consentimiento informado, a los que se realiz\u00f3 la exodoncia de un tmi submucoso, osteomucoso o endo\u00f3seo, con anestesia local.  tratamiento: g1=irrigaci\u00f3n con clorhexidina 0,12% en el alveolo, 500 mg de diflunisal cada 12 horas\/2 d\u00edas, un comprimido de antibi\u00f3tico\/8h\/4 d\u00edas y colutorio de clorhexidina 0,12%\/8h\/7 d\u00edas. En g2 se sustituye el antibi\u00f3tico por placebo, m\u00e9todo: se han registrado durante las 8 semanas posteriores a la cirug\u00eda, signos y s\u00edntomas de infecci\u00f3n, y variables de control.  resultados: g1=259 pacients y g2=231. Frecuencia de infecci\u00f3n: g1=1,9%, g2=12,9%(p menor 0,05) (un paciente de g1 ha precisado ingreso), medidas de riesgo ic 95%: or ajustada 8,66(3,17-23,67), rrr 85%(61%-94%), arr 0,11(0,066-0,155) no podemos rechazar la hip\u00f3t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ensayo cl\u00ednico sobre la eficacia de la amoxicilina\/\u00e1c. clavul\u00e1nico frente a placebo, en la prevenci\u00f3n de infecci\u00f3n postoperatoria, tras la exodoncia de terceros molares inferiores incluidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ensayo cl\u00ednico sobre la eficacia de la amoxicilina\/\u00e1c. clavul\u00e1nico frente a placebo, en la prevenci\u00f3n de infecci\u00f3n postoperatoria, tras la exodoncia de terceros molares inferiores incluidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Diez Garcia M. Antonia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/01\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joseba Santamaria Zuazua<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Goiriena de gandarias javier <\/li>\n<li> Gutierrez perez Jos\u00e9 Luis (vocal)<\/li>\n<li>Emilio Jimenez castellanos ballesteros (vocal)<\/li>\n<li>Elena Sanchez hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diez Garcia M. Antonia La exodoncia del tercer molar inferior (tmi) representa entre un 40%-60% de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[80282,80283,22935,25499,3003,10668],"class_list":["post-28098","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-diez-garcia-m-antonia","tag-elena-sanchez-hernandez","tag-emilio-jimenez-castellanos-ballesteros","tag-goiriena-de-gandarias-javier","tag-gutierrez-perez-jose-luis","tag-joseba-santamaria-zuazua"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28098"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28098\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}