{"id":28157,"date":"2018-03-09T09:20:44","date_gmt":"2018-03-09T09:20:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-mecanismos-implicados-en-la-aparicion-de-trombosis-glomerular-asociada-a-la-endotoxemia\/"},"modified":"2018-03-09T09:20:44","modified_gmt":"2018-03-09T09:20:44","slug":"estudio-de-los-mecanismos-implicados-en-la-aparicion-de-trombosis-glomerular-asociada-a-la-endotoxemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/estudio-de-los-mecanismos-implicados-en-la-aparicion-de-trombosis-glomerular-asociada-a-la-endotoxemia\/","title":{"rendered":"Estudio de los mecanismos implicados en la aparici\u00f3n de trombosis glomerular asociada a la endotoxemia"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1inz Garc\u00eda Silvia Raquel <\/strong><\/h2>\n<p>Tnf puede inducir trombosis glomerular independientemente de la activaci\u00f3n de la v\u00eda no. Sin embargo, se ignoran los mecanismos celulares y moleculares implicados en la aparici\u00f3n de trombosis. Por ello, en el presente proyecto se analizar\u00e1 si tnf ejerce une fecto directo sobre las c\u00e9lulas del glom\u00e9rulo o, por si el contrario, la inducci\u00f3n de trombosis glomerular es consecuencia de la acci\u00f3n de tnf sobre c\u00e9lulas accesorias, las cuales a su vez inducir\u00edan trombosis. Tambi\u00e9n se analiza si la expresi\u00f3n de fosfatidilserina (ps) por parte de c\u00e9lulas glomerulares contribuye a la aparici\u00f3n de trombosis y, por \u00fatlimo, investigamos, si el bloqueo de alg\u00fan componente de los que participan en la transmisi\u00f3n de se\u00f1ales v\u00eda receptor fas podr\u00eda impedir la aparici\u00f3n de trombosis. Para ello se emplean ratas sprague-dqley y ratones deficientes en fas, a los que se les inducir\u00e1 trombosis glomerular mediante la administraci\u00f3n de lps+l-name. Se recogen muestras de sangre, orina y tejido renal. Tras los resultados obtenidos se sugiere que el tnf juega unpapel primordial pero neceista unirse al receptor fas para ejercer su acci\u00f3n. Cuano fas se activa se generan una transmisi\u00f3n de se\u00f1ales hacia el interior celular que producen una alteraci\u00f3n en los fosfol\u00edpidos de membrana (ps) y esto genera efectos protrombog\u00e9nicos, con el consecuente dep\u00f3sito de fibrina y la formaci\u00f3n del trombo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los mecanismos implicados en la aparici\u00f3n de trombosis glomerular asociada a la endotoxemia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los mecanismos implicados en la aparici\u00f3n de trombosis glomerular asociada a la endotoxemia <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1inz Garc\u00eda Silvia Raquel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/01\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Castillo Caba Domingo Del<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Pe\u00f1a Martinez <\/li>\n<li>Rafael Ramirez chamond (vocal)<\/li>\n<li>Antonio Osuna ortega (vocal)<\/li>\n<li>Alberto Tejedor Jorge (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1inz Garc\u00eda Silvia Raquel Tnf puede inducir trombosis glomerular independientemente de la activaci\u00f3n de la v\u00eda no. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973],"tags":[15545,35817,80409,13,80410,80408],"class_list":["post-28157","post","type-post","status-publish","format-standard","hentry","category-cordoba","tag-alberto-tejedor-jorge","tag-antonio-osuna-ortega","tag-castillo-caba-domingo-del","tag-jose-pena-Martinez","tag-rafael-ramirez-chamond","tag-sainz-garcia-silvia-raquel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28157"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28157\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}